基于信号通路的中药治疗糖尿病足溃疡作用机制研究进展  

Research progress in the mechanism of TCM in the treatment of diabetic foot ulcer based on signaling pathway

作　　者：顾召 夏联恒 高杰[2] Gu Zhao;Xia Lianheng;Gao Jie(Doctoral Degree Student of Grade 2022,Heilongjiang University of Chinese Medicine,Harbin 150040,China;Department of Peripheral Vascular Disease,the First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学,哈尔滨150040 [2]黑龙江中医药大学附属第一医院周围血管病科,哈尔滨150040

出　　处：《国际中医中药杂志》2025年第3期429-432,F0003,共5页International Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金(82305253);黑龙江省自然科学基金(LH2022H075)。

摘　　要：中药治疗糖尿病足溃疡主要涉及Wnt、核转录因子红系2相关因子2(Nrf2)、PI3K/Akt、NF-κB信号通路、Notch、TGF-β/Smad及HIF-1α/VEGF信号通路。中药单体、复方及提取物等可通过调节相关信号通路,减少炎症因子释放,抗氧化应激,促进血管及肉芽组织新生,从而促进创面愈合。TCM treatment for diabetic foot ulcers mainly involves Wnt,Nrf2,PI3K/Akt,NF-κB signaling pathway,Notch,TGF-β/Smad and HIF-1α/VEGF signaling pathway.TCM monomers,compounds and extracts can promote wound healing by regulating related signaling pathways,reducing the release of inflammatory factors,anti-oxidative stress,and promoting angiogenesis and granulation tissue regeneration.

关 键 词：糖尿病足 足溃疡 信号通路 研究进展 综述 

分 类 号：R73[医药卫生—肿瘤]