大柴胡汤加减辅助治疗急性胰腺炎(腑实热结证)的临床观察  

Clinical Observation of Modified Dachaihu Decoction as an Adjunctive Therapy for Acute Pancreatitis(Syndrome of Fu-organ Excess and Heat Accumulation)

作　　者：曾渊杰 宋晓龙 薛寅 Zeng Yuanjie;Song Xiaolong;Xue Yin(Wujin Hospital Affiliated to Jiangsu University,Wujin Clinical College of Xuzhou Medical University,Jiangsu,Changzhou 213000,China)

机构地区：[1]江苏大学附属武进医院,徐州医科大学武进临床学院,江苏常州213000 [2]江苏省盐城市中医院,江苏盐城224001

出　　处：《中国中医急症》2025年第3期491-494,共4页Journal of Emergency in Traditional Chinese Medicine

基　　金：江苏省卫健委2022年度省老年健康科研项目(LKM2022076)。

摘　　要：目的观察大柴胡汤加减辅助治疗对急性胰腺炎(腑实热结证)患者中医证候及血清水通道蛋白5(AQP5)、D-乳酸(D-LA)的影响。方法纳入108例急性胰腺炎(腑实热结证)患者,按照随机数字表法分为常规组、中药组,每组54例。常规组行常规西医治疗,中药组在常规组基础上予以大柴胡汤加减辅助治疗,治疗周期2周。对比两组治疗有效率、中医证候积分、血清AQP5及D-LA水平、炎症因子水平、临床症状缓解时间。结果中药组临床总有效率为94.44%,高于常规组的79.63%(P<0.05)。中药组中医证候积分均低于常规组(P<0.05)。中药组血清AQP5水平高于常规组(P<0.05),血清D-LA、C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平均低于常规组(P<0.05);中药组腹痛、腹胀症状缓解时间均短于常规组(P<0.05)。结论大柴胡汤加减辅助治疗对急性胰腺炎(腑实热结证)患者具有较好临床疗效。Objective:To investigate the effect of Modified Dachaihu Decoction as adjuvant therapy on traditional Chinese medicine syndromes and serum aquaporin 5(AQP5)and D-lactic acid(D-LA)in patients with acute pancreatitis(syndrome of fu-organ excess and heat accumulation).Methods:A total of 108 patients with acute pancreatitis(syndrome of fu-organ excess and heat accumulation)were divided randomly into the control group and the traditional Chinese medicine group,with 54 cases in each group.The former was given conventional western medicine treatment,and the latter was given adjuvant therapy with Modified Dachaihu Decoction on this basis.Both groups underwent 2 weeks of treatment.The two groups were compared on clinical efficacy,traditional Chinese medicine syndrome scores,serum AQP5 and D-LA levels,inflammatory factor levels,and clinical symptom relief time.Results:The overall clinical efficacy rate in the TCM group(94.44%)was significantly higher than that in the conventional group(79.63%)(P<0.05).The TCM syndrome scores in the TCM group were lower than those in the conventional group(P<0.05).Serum AQP5 levels in the TCM group were higher than those in the conventional group(P<0.05),while serum D-LA,C-reactive protein(CRP),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α)levels were lower in the TCM group compared with the conventional group(P<0.05).The relief times for abdominal pain and abdominal distension symptoms were shorter in the TCM group than in the conventional group(P<0.05).Conclusion:Modified Dachaihu Decoction as an adjuvant therapy demonstrates good clinical efficacy for patients with acute pancreatitis(syndrome of fu-organ excess and heat accumulation).

关 键 词：急性胰腺炎 大柴胡汤 腑实热结证 AQP5 D-LA 

分 类 号：R576[医药卫生—消化系统]