基于隐结构模型结合关联规则探讨代谢相关脂肪性肝病的基础证候特征  

Exploring the basic syndrome characteristics of metabolic associated fatty liver disease based on latent structure model and association rules

作　　者：王叶 何佳 郑佳连[1] 闵冬雨[1] 卢秉久[1] WANG Ye;HE Jia;ZHENG Jia-lian;LU Bing-jiu(Liaoning University of Traditional Chinese Medicine Affiliated Hospital(Shengyang,110032),China.)

机构地区：[1]辽宁中医药大学附属医院,辽宁沈阳110032 [2]辽宁中医药大学附属第四医院

出　　处：《中西医结合肝病杂志》2025年第3期277-282,共6页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：国家中医药管理局(No.2022-304),省自然基金资助计划(2019-MS-231),沈阳市科学技术计划(21-173-9-09)。

摘　　要：目的:探讨代谢相关脂肪性肝病(MAFLD)常见基础证候分布及特征,为辨证规范及证候疗效评价提供诊疗依据。方法:检索中文数据库中自建库至2023年8月31日MAFLD证候相关文献;采用SPSS 20.0软件,建立数据库并进行统计描述分析;采用SPSS Modeler 18.0软件,基于Apriori算法,对证素进行关联规则分析;采用Latern 5.0软件,基于LTM-EAST算法,构建症状隐结构模型并进行综合聚类分析。结果:①纳入MAFLD证候相关文献203篇,涉及基础证候16个,证素16个,症状85个;②频率≥10%且累计构成比≥75%的基础证候有:痰湿证、脾气虚证、肝郁气滞证、血瘀证;③对证素进行关联规则分析,得出强关联规则32条,推断脾气虚证、肝郁气滞证、痰湿证、血瘀证等4个基础证候;④对频次≥5%的症状进行隐结构分析,得到13个隐变量、26个隐类;进行综合聚类得到5个综合聚类模型,推断出脾气虚证、肝郁气滞证、痰湿证、血瘀证、湿(痰)热证等5个基础证候。综合上述方法,最终得出4个常见基础证候。结论:MAFLD常见基础证候有脾气虚证、肝郁气滞证、痰湿证、血瘀证,证属虚实夹杂。Objective:To explore the distribution and characteristics of common basic syndromes in metabolic associated fatty liver disease(MAFLD),and provide diagnostic and therapeutic basis for standardized syndrome differentiation and evaluation of syndrome efficacy.Methods:Retrieving literature related to MAFLD syndrome from inception in Chinese databases until August 31,2023.Using SPSS 20.0 software,establish a database and conduct statistical descriptive analysis.Using SPSS Modeler 18.0 software and Apriori algorithm,conduct association rule analysis on evidence elements.Using Latern 5.0 software and LTM-EAST algorithm,construct a symptom hidden structure model and perform a comprehensive clustering analysis.Results:(1)A total of 203 MAFLD syndrome related literature were included,involving 16 basic syndromes,16 syndrome elements,and 85 symptoms.(2)The basic syndromes with a frequency of≥10%and a cumulative composition ratio of≥75%include:phlegm dampness syndrome,spleen qi deficiency syndrome,liver depression and qi stagnation syndrome,and blood stasis syndrome.(3)Analyzing the association rules of syndrome elements,32 strong association rules were obtained,and four basic syndromes were inferred,including spleen qi deficiency syndrome,liver depression and qi stagnation syndrome,phlegm dampness syndrome,and blood stasis syndrome Perform hidden structure analysis on symptoms with a frequency of≥5%,resulting in 13 hidden variables and 26 hidden classes.Five comprehensive clustering models were obtained through comprehensive clustering,and five basic syndromes were inferred,including spleen qi deficiency syndrome,liver depression,and qi stagnation syndrome,phlegm dampness syndrome,blood stasis syndrome,and dampness(phlegm)heat syndrome.Based on the above methods,four common basic syndromes were ultimately identified.Conclusion:The common basic syndromes of MAFLD include spleen qi deficiency syndrome,liver depression and qi stagnation syndrome,phlegm dampness syndrome,and blood stasis syndrome,which belong to a combin

关 键 词：关联规则 隐结构模型 代谢相关脂肪性肝病 基础证候 

分 类 号：R575.5[医药卫生—消化系统]