基于文献挖掘的酒精性肝病中医证候要素及辨证规律研究  

Research on TCM syndrome elements and syndrome differentiation rules of alcoholic liver disease based on literature mining

作　　者：黄娜菲 崔艺馨 冯晓峰 高斐 章晨怡 陈小梅 孙涛 HUANG Na-fei;CUI Yi-xin;FENG Xiao-feng;SUN Tao(The Second Clinical Medical College of Zhejiang Chinese Medical University,Hangzhou,310053,China)

机构地区：[1]浙江中医药大学第二临床医学院,浙江杭州310053 [2]浙江中医药大学附属第二医院肝病科

出　　处：《中西医结合肝病杂志》2025年第3期283-289,共7页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：国家中医药管理局科技司-浙江省中医药管理局共建科技计划项目(No.GZY-ZJ-KJ-24071);浙江省中医药科技计划项目(No.2023ZL446)。

摘　　要：目的:基于文献数据分析,探讨酒精性肝病(ALD)常见中医证候分类及特征,为临床辨证和证候规范提供参考。方法:检索2013年1月至2024年1月中国知网、万方数据库、维普数据库中ALD中医证候的相关文献,筛选出符合要求的文献并构建数据库,运用统计描述、关联规则网络、隐结构模型进行数据频次和关联性分析,确定ALD常见中医证候及症状特征。结果:符合要求的文献149篇,构成比≥5%的病位证素有肝、脾、胃、胆;病性证素有湿、气滞、气虚、热、痰、血瘀;基础证候有脾气虚证、湿热蕴结证、肝郁证、痰湿证、气滞证、血瘀证;症状有胁肋疼痛、脘腹胀满、食少纳呆、倦怠乏力。证素关联规则分析及隐结构聚类分析推断出脾气虚证、肝郁脾虚证、湿热蕴结证、血瘀证、肾阴虚证5个证候。结论:ALD病位主要在肝和脾;明显症状有胁肋疼痛、脘腹胀满、食少纳呆、倦怠乏力;病性证素以湿、热、气滞、气虚为主;基础证候为湿热蕴结证、肝郁脾虚证、脾气虚证。Objective:Objective Based on the literature data,this paper explores the classification and characteristics of common syndromes of alcoholic liver disease(ALD),to provide a reference for clinical syndrome differentiation and pattern standardization research.Methods:Literature related to ALD syndromes in the China National Knowledge Infrastructure,Wanfang Data,and VIP Database for Chinese Technical Periodicals were searched from January 2013 to January 2024.The literature that meets the requirements was screened out and a database was constructed,and the statistical description,association rule network,and hidden structure model were used to analyze the data frequency and correlation to determine the common syndromes and symptom characteristics of ALD.Results:There were 149 papers that met the requirements,the syndromes that constituted≥5%were liver,spleen,stomach,and gallbladder;pathological syndromes include dampness,qi stagnation,qi deficiency,heat,phlegm,and blood stasis;the basic syndromes include spleen qi deficiency pattern,damp-heat accumulation pattern,liver stagnation pattern,phlegm-dampness pattern,qi stagnation pattern,and blood stasis pattern;symptoms include flank pain,abdominal distention,eat less,fatigue and fatigue.Pattern element association rule analysis and hidden structure cluster analysis deduced five syndromes:spleen qi deficiency pattern,liver depression and spleen deficiency pattern,damp-heat accumulation pattern,blood stasis pattern,and kidney yin deficiency pattern.Conclusion:ALD is mainly located in the liver and spleen.The main symptoms of ALD are flank pain,abdominal distention,lack of appetite,fatigue,and fatigue;the main pathological syndromes are dampness,heat,qi stagnation,and qi deficiency;and the basic syndromes are damp-heat accumulation pattern,liver depression and spleen deficiency pattern,and spleen qi deficiency pattern.

关 键 词：酒精性肝病 中医证候 统计描述 关联规则 隐结构 

分 类 号：R575.5[医药卫生—消化系统]