清肝化痰活血方降低非酒精性脂肪性肝炎患者5年肝硬化发生率的疗效分析  

Evaluation of the efficacy of the Qinggan Huatan Huoxue formula in reducing the five-year incidence of cirrhosis in patients with non-alcoholic steatohepatitis

作　　者：周洋 陈佳良 孟培培[1] 冀晓敏 江宇泳[1] 侯艺鑫[1] ZHOU yang;CHEN jia-liang;MENG pei-pei;HOU YI-xin(Department of Center of Integrated Traditional Chinese and Western Medicine,Beijing Ditan Hospital,Capital Medical University(Beijing,100015),China.)

机构地区：[1]首都医科大学附属北京地坛医院中西医结合中心,北京100015

出　　处：《中西医结合肝病杂志》2025年第3期290-294,共5页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：国家重点研发项目(No.20232023YFC230880);北京市高层次公共技术人才项目(学科骨干-03-07)。

摘　　要：目的:探讨清肝化痰活血方对非酒精性脂肪性肝炎(NASH)患者5年内发生肝硬化的效果。方法:纳入2015年1月至2018年1月北京地坛医院就诊并符合纳入标准的NASH患者共427例,随访5年。根据患者是否发生肝硬化,将其分为肝硬化组和非肝硬化组。通过Logistic回归方法分析影响肝硬化发生的独立危险因素,并观察清肝化痰活血方对预防NASH患者进展至肝硬化的作用。结果:是否接受清肝化痰活血方治疗是影响NASH患者5年内是否进展至肝硬化的独立危险因素之一。通过1∶1倾向性评分对两组患者进行匹配,在两组患者基线特征一致的情况下,中药组患者5年内肝硬化发生率为5.7%,对照组患者为13.3%(P<0.001);两组患者自随访至发生肝硬化时间,中药组患者为(4.0±0.2)年,对照组患者为(3.5±0.3)年(P<0.001)。结论:清肝化痰活血方能够有效降低NASH患者5年内进展至肝硬化的风险,延缓患者肝硬化发生时间。Objective:The study aimed to investigate the impact of Qinggan Huatan Huoxue formula on cirrhosis development in non-alcoholic steatohepatitis(NASH)patients over a five-year period.Methods:A total of 427 NASH patients were collected between January 2015 and January 2018.All patients underwent a five-year follow-up during which independent risk factors for liver cirrhosis were analyzed using logistic regression.The study observed the effect of Qinggan Huatan Huoxue formula in preventing NASH patients from progressing to liver cirrhosis.Results:the use of Qinggan Huatan Huoxue formula was identified as an independent risk factor for NASH patients progressing to cirrhosis within five years.The incidence of liver cirrhosis was 5.7%in the TCM recipe group compared to 13.3%in the control group with a 1∶one propensity score(P<0.001).The time from follow-up to cirrhosis was 4.0±0.2 years in the TCM group and 3.5±0.3 years in the control group(P<0.001).Conclusion:Qinggan Huatan Huoxue formula demonstrated efficacy in reducing the risk of liver cirrhosis in NASH patients over a five-year period and effectively delayed the onset of cirrhosis.

关 键 词：非酒精性脂肪性肝炎 肝硬化 中医药 清肝化痰活血方 

分 类 号：R575.2[医药卫生—消化系统]