107例儿童肺炎支原体肺炎并发肝损害患儿的高危因素分析  

High risk factors for liver damage in 107 children with mycoplasma pneumo-niae pneumonia

作　　者：郝琳 刘怀彬 毕颖 HAO Lin;LIU Huai-bin;BI Ying(Xuzhou Children′s Hospital,Xuzhou Jiangsu,221000,China.)

机构地区：[1]徐州市儿童医院,江苏徐州221000

出　　处：《中西医结合肝病杂志》2025年第3期314-317,共4页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：徐州市儿童医院科研项目(No.23040422)。

摘　　要：目的:分析儿童肺炎支原体肺炎(MPP)并发肝损害的危险因素。方法:本研究纳入107例MPP并发肝损害患儿的临床资料,并选取同期住院的110例MPP无肝损害患儿作为对照组,通过单因素及多因素分析,对两组患儿的临床特征及相关指标进行对比分析,绘制ROC曲线分析MPP并发肝损害危险因素的预测效能。结果:两组患儿在住院时间、热程、热峰(≥39.0℃)、激素应用时间、淋巴细胞百分比(LYM%)、红细胞分布宽度(RDW)、Hb、C反应蛋白(CRP)、碱性磷酸酶(ALP)、总蛋白(TP)、白蛋白(Alb)、球蛋白(GLO)、乳酸脱氢酶(LDH)、肌酸激酶同工酶(CK-MB)、α-羟丁酸脱氢酶(α-HBDH)、发生肺实变、病变累及肺叶≥2个差异均有统计学意义(均P<0.05);多因素Logistic回归分析显示,热程、热峰(≥39.0℃)、LYM%、RDW、LDH、病变累及肺叶≥2个为导致儿童MPP并发肝损害的独立危险因素;ROC曲线的曲线下面积分别为0.700、0.713、0.809。结论:MPP并发肝损害的原因复杂,需要根据患儿的临床症状、实验室及影像学等指标,提前制定科学防治方案。Objective:Analyze the risk factors for liver damage in children with mycoplasma pneumoniae pneumonia(MPP).Methods:Selecting clinical data of 107 children with MPP complicated with liver damage admitted to our hospital from January 2020 to August 2023.Then,we selected 110 children without MPP complicated with liver damage admitted during the same period as the control group,conducting univariate and multivariate analysis of clinical related data of the two groups of children,and drawing ROC curves to analyze the predictive efficacy of risk factors for MPP complicated with liver damage.Results:In terms of hospitalization time,fever duration,fever peak(≥39.0℃),hormone application time,LYM%,RDW,Hb,CRP,ALP,TP,Alb,LDH,CK-MBα-There were statistically significant differences(P<0.05)in HBDH,occurrence of lung consolidation,and involvement of lung lobes by≥2 lesions.Conclusion:The causes of liver damage in children with MPP are complex,including heat duration,heat peak(≥39.0℃),LYM%,RDW,LDH,and involvement of more than two lobes of the lungs.Clinical needs to develop scientific prevention and treatment plans in advance based on the patient's clinical symptoms,laboratory,and imaging indicators to improve prognosis.

关 键 词：儿童 肺炎支原体肺炎 肝损害 高危因素 

分 类 号：R575[医药卫生—消化系统]