入院时NIHSS评分联合血浆Copeptin、D-二聚体对急性缺血性脑卒中患者的病情进展评估价值分析  

Evaluation Value Analysis of NIHSS Score Combined with Plasma Copeptin and D-dimer in Patients with Acute Ischemic Stroke

作　　者：卢克红 Lu Kehong(Emergency Department of Beicheng Hospital,Linyi Traditional Chinese Medicine Hospital,Linyi,Shandong,276000 China)

机构地区：[1]临沂市中医医院北城医院急诊科,山东临沂276000

出　　处：《哈尔滨医药》2025年第1期8-10,共3页Harbin Medical Journal

摘　　要：目的探究入院时美国国立卫生研究院卒中量表(NIHSS)评分联合血浆和肽素(Copeptin)、D-二聚体对急性缺血性脑卒中(AIS)患者的病情进展评估价值。方法选取AIS患者90例进行研究,依据入院NIHSS评分分为轻中度组(≤15分,n=67)和重度组(>15分,n=23),纳入同期体检的健康人员40例为健康组。比较NIHSS评分、血浆Copeptin、D-二聚体水平差异,分析Copeptin、D-二聚体水平与AIS患者病情进展的相关性,二元logistic分析Copeptin、D-二聚体水平与病情进展的关系,ROC分析Copeptin和D-二聚体对AIS患者病情进展的评估价值。结果AIS组和重度组患者NIHSS评分和Copeptin、D-二聚体水平高于健康组和轻中度组(P<0.05);Copeptin、D-二聚体水平与AIS患者病情进展呈正相关(P<0.05);二元logistics回归分析显示,Copeptin和D-二聚体水平是AIS患者病情进展的相关影响因素(P<0.05);ROC结果显示,Copeptin和D-二聚体评估AIS患者病情进展的AUC分别为0.933、0.969,联合诊断的AUC为0.988,敏感度为95.65%,特异度为82.09%。结论AIS患者病情进展的血浆Copeptin、D-二聚体水平较高,与入院NIHSS评分有一定相关性,是病情进展的相关影响因素,临床诊断有一定参考价值。Objective To explore the value of National Institutes of Health Stroke Scale(NIHSS)score combined with plasma and peptidogysin(Copeptin)and D-dimer for disease progression in patients with acute ischemic stroke(AIS).Methods 90 AIS patients were selected for the study.According to the NIHSS score,they were mild into moderate group(15 points,n=67)and severe group(>15 points n=23),and 40 healthy patients included in the physical examination in the same period were healthy group.Comparing differences in NIHSS scores,plasma Copeptin and D-dimer levels,analyzed the correlation between Copeptin and D-dimer levels and disease progression in AIS patients,binary logistic analyzed the relationship between Copeptin and D-dimer levels and disease progression,and ROC analyzed the value of Copeptin and D-dimer on disease progression in AIS patients.Results NIHSS score and Copeptin and D-dimer levels in AIS and severe group were higher than healthy and mild to moderate groups(P<0.05);Copeptin,D-dimer levels were positively correlated with disease progression in AIS patients(P<0.05);Binary logistics regression analysis showed that,Copeptin And D-dimer levels were related factors affecting disease progression in AIS patients(P<0.05);ROC result display,The AUC of Copeptin and D-dimer evaluation for the disease progression in AIS patients were 0.933 and 0.969,respectively,The AUC for the combined diagnosis was 0.988,A sensitivity of 95.65%,The specificity ratio was 82.09%.Conclusion The plasma levels of Copeptin and D-dimer in AIS patients are high,which are correlated with admission NIHSS score,are the relevant influencing factors of disease progression,and have certain reference value in clinical diagnosis.

关 键 词：急性缺血性脑卒中 NIHSS评分 和肽素 D-二聚体 病情进展 

分 类 号：R743.3[医药卫生—神经病学与精神病学]