白蛋白生理功能再认识  

A re-understanding of the physiological function of albumin

作　　者：王菁菁 刘丽改[1] 谢雯[1] WANG Jingjing;LIU Ligai;XIE Wen(Liver Research Center,Beijing Ditan Hospital,Capital Medical University,Beijing 100015,China)

机构地区：[1]首都医科大学附属北京地坛医院肝病中心,北京100015

出　　处：《临床肝胆病杂志》2025年第3期404-408,共5页Journal of Clinical Hepatology

基　　金：北京市医院管理中心“杨帆”计划临床技术创新项目(ZLRK202334)。

摘　　要：白蛋白作为肝脏合成的重要蛋白质,是反映肝功能的重要标志之一,可随着肝损伤的进展而发生结构和功能变化。在疾病状态下,白蛋白不仅是数量减少,功能也受损,在此基础上提出了“有效白蛋白”概念。本文对白蛋白的生理结构和功能、在疾病状态下的生理功能变化及有效白蛋白的研究进展进行阐述,以探索更精准的白蛋白临床应用策略。As an important protein synthesized by the liver,albumin is one of the most important markers for liver function,and its structure and function change with the progression of liver injury.Latest studies have shown that albumin in the disease state is not only reduced in quantity,but also damaged in quality,and thus the concept of“effective albumin”was proposed.This article elaborates on the research advances in the physiological structure and function of albumin,the changes of physiological function in the disease state,and the research advances in effective albumin,so as to explore precise strategies for the clinical application of albumin.

关 键 词：白蛋白类 有效白蛋白 肝硬化 

分 类 号：R73[医药卫生—肿瘤]