非酒精性脂肪性肝病中医/中西医结合诊疗指南/共识的质量评价  

Quality assessment of guidelines/consensuses on traditional Chinese medicine/integrated traditional Chinese and Western medicine diagnosis and treatment of nonalcoholic fatty liver disease

作　　者：焦睿珉 赵静洁[1,3] 李娟娟 陈伟 韩超汝 李丽 徐春军 尤红[2] JIAO Ruimin;ZHAO Jingjie;LI Juanjuan;CHEN Wei;HAN Chaoru;LI Li;XU Chunjun;YOU Hong(Department of Traditional Chinese Medicine,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China;Liver Research Center,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China;Clinical Center for Metabolic Associated Fatty Liver Disease,Capital Medical University,Beijing 100050,China;Department of Acupuncture and Moxibustion(Division 2),Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 101121,China;Department of Liver Diseases,Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China)

机构地区：[1]首都医科大学附属北京友谊医院中医科,北京100050 [2]首都医科大学附属北京友谊医院肝病中心,北京100050 [3]首都医科大学中西医结合代谢相关脂肪性肝病临床诊疗与研究中心,北京100050 [4]北京中医药大学东直门医院针灸科二区,北京101121 [5]首都医科大学附属北京中医医院肝病科,北京100010

出　　处：《临床肝胆病杂志》2025年第3期446-452,共7页Journal of Clinical Hepatology

基　　金：国家自然科学基金(82405192);北京市重大疑难疾病中西医协同攻关项目(2023BJSZDYNJBXTGG017);高层次公共卫生技术人才建设项目(学科骨干-03-40);首都卫生发展科研专项(首发2022-2-20213,2022-1-2021);首都医科大学附属北京友谊医院“种子计划”项目(YYZZ202333)。

摘　　要：目的评价已发表的非酒精性脂肪性肝病(NAFLD)中医/中西医结合诊疗指南/共识的方法学和报告质量,以期为今后代谢相关脂肪性肝病中医/中西医结合指南/共识的制定提供参考依据。方法计算机检索PubMed、Embase、Web of Science、中国知网、万方和中国生物医学文献数据库,以及中华中医药学会和中国中西医结合学会的网站(自建库至2024年9月1日)。由两位临床研究人员分别使用指南的研究和评估工具第二版(AGREEⅡ)和国际实践指南报告规范(RIGHT)评价纳入NAFLD中医/中西医结合诊疗指南/共识的方法学质量及报告质量。结果通过文献筛选,最终纳入9篇指南/共识,其中指南4篇,专家共识5篇;采用AGREEⅡ评价9篇指南/共识不同领域得分依次为范围和目的(47.1%)、参与人员(41.0%)、严谨性(21.6%)、清晰性(40.2%)、应用性(19.1%)、独立性(19.6%)。文献推荐级别划分为:B级(修订后推荐)4篇,C级(不推荐)5篇。RIGHT评估显示,“基本信息”与“证据”报告率高,其他领域有待提升。目前,对于NAFLD的中医/中西医结合诊疗指南/共识,尚无国际标准且质量需加强以确保全面性和可信度。结论NAFLD中医/中西医结合诊疗指南/共识的质量仍有提升潜力,应严格遵循AGREEⅡ与RIGHT清单,以确保指南/共识的公正性、科学性与透明度。Objective To evaluate the methodological quality and reporting quality of published guidelines/consensuses on traditional Chinese medicine(TCM)/integrated traditional Chinese and Western medicine diagnosis and treatment of nonalcoholic fatty liver disease(NAFLD),and to provide a basis for formulating guidelines/consensuses on TCM/integrated traditional Chinese and Western medicine diagnosis and treatment of NAFLD in the future.Methods Databases including PubMed,Embase,Web of Science,CNKI,Wanfang Data,and CBM and the websites of China Association of Chinese Medicine and China Association of Integrative Medicine were searched for related articles published up to September 1,2024.Two clinical researchers independently assessed the methodological quality and reporting quality of the guidelines/consensuses on TCM/integrated traditional Chinese and Western medicine diagnosis and treatment of NAFLD by using Appraisal of Guidelines for Research and EvaluationⅡ(AGREEⅡ)and Reporting Items for Practice Guidelines in Healthcare(RIGHT).Results A total of nine guidelines/consensuses were included after literature screening,with four guidelines and five expert consensuses.The scores of different domains assessed by AGREEⅡfor the nine guidelines/consensuses were as follows:scope and purpose(47.1%),stakeholder involvement(41.0%),rigor of development(21.6%),clarity of presentation(40.2%),applicability(19.0%),and editorial independence(19.6%).The recommendation level of the articles was B level(recommended after revision)for four articles and C level(not recommended)for five articles.The RIGHT assessment showed high reporting rates for“Basic Information”and“Background”,while other areas needed to be improved.Currently,there was no international standard for the guidelines/consensuses on TCM/integrated traditional Chinese and Western medicine diagnosis and treatment of NAFLD,and the quality of these guidelines/consensuses needed to be enhanced to ensure comprehensiveness and credibility.Conclusion There is still potent

关 键 词：非酒精性脂肪性肝病 医学 中国传统 中西医结合 诊疗准则(主题) 共识 

分 类 号：R57[医药卫生—消化系统]