氨基酸代谢在自身免疫性肝炎中的作用机制及相关治疗靶点  

Role of amino acid metabolism in autoimmune hepatitis and related therapeutic targets

作　　者：郭佩佩 徐洋 石嘉琪 伍杨 卢利霞 李斌[2] 于晓辉 GUO Peipei;XU Yang;SHI Jiaqi;WU Yang;LU Lixia;LI Bin;YU Xiaohui(Department of Gastroenterology,The Second Hospital of Lanzhou University,Lanzhou 730030,China;The First Clinical Medical College of Gansu University of Chinese Medicine,Lanzhou 730000,China;Department of Gastroenterology,The 940th Hospital of Joint Logistic Support Force of PLA,Lanzhou 730050,China)

机构地区：[1]兰州大学第二医院消化内科,兰州730030 [2]甘肃中医药大学第一临床医学院,兰州730000 [3]中国人民解放军联勤保障部队第九四〇医院消化内科,兰州730050

出　　处：《临床肝胆病杂志》2025年第3期547-551,共5页Journal of Clinical Hepatology

基　　金：甘肃省科技计划项目青年科技基金(23JRRA1675);甘肃省科技计划项目重点研发计划-社发类(22YF7FA105)。

摘　　要：自身免疫性肝炎(AIH)是一种慢性炎症性肝病,其发病机制目前尚不清楚,主要是免疫系统的异常激活,导致自身免疫耐受性破坏引起的自身免疫性损伤,但其更为具体的分子机制并不十分清楚。最近的研究表明,氨基酸代谢异常在AIH发病及疾病进展中起着重要作用。本文围绕氨基酸代谢重编程在AIH中的研究进展进行综述,为氨基酸代谢作为AIH临床诊断和治疗的新靶点提供理论依据。Autoimmune hepatitis(AIH)is a chronic inflammatory liver disease.The pathogenesis of AIH remains unclear,but it is mainly autoimmune injury caused by the breakdown of autoimmune tolerance due to the abnormal activation of the immune system,while the specific molecular mechanism remains unknown.Recent studies have shown that abnormal amino acid metabolism plays an important role in the development and progression of AIH.This article reviews the research advances in amino acid metabolic reprogramming in AIH,in order to provide a theoretical basis for amino acid metabolism as a new target for the clinical diagnosis and treatment of AIH.

关 键 词：肝炎 自身免疫性 氨基酸类 分子靶向治疗 

分 类 号：R57[医药卫生—消化系统]