胆-肠轴在肝内胆管癌发生发展中的作用机制  

Mechanism of action of bile-gut axis in the development and progression of intrahepatic cholangiocarcinoma

作　　者：俞雪 沈天皓 周诚 刘雨 李炜[2] 蒋霆辉[1] 朱永强 刘艳[1] YU Xue;SHEN Tianhao;ZHOU Cheng;LIU Yu;LI Wei;JIANG Tinghui;ZHU Yongqiang;LIU Yana(Department of Interventional Oncology,Putuo Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200062,China;Department of Hepatobiliary Minimally Invasive Surgery,Putuo Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200062,China)

机构地区：[1]上海中医药大学附属普陀医院肿瘤介入科,上海200062 [2]上海中医药大学附属普陀医院肝胆微创外科,上海200062

出　　处：《临床肝胆病杂志》2025年第3期588-593,共6页Journal of Clinical Hepatology

基　　金：上海市卫生健康委员会青年人才计划(2022YQ037);上海市普陀区卫生健康系统科技创新项目计划(ptkwws202210);上海市普陀区中心医院临床匠才计划(2022-RCJC-07)。

摘　　要：肝内胆管癌是一种预后极差的恶性肿瘤,其发病机制复杂且尚未完全明确。近年来,越来越多的研究聚焦于胆-肠轴在肝内胆管癌发生发展中的作用。胆-肠轴是指胆汁和肠道微生物群之间的复杂交互作用,包括胆盐代谢、微生物群的动态变化、炎症反应以及免疫系统的调节等多方面内容。本文系统阐述了胆-肠轴在肝内胆管癌中的潜在机制,特别是微生物群失调、胆盐代谢异常、慢性炎症反应及免疫系统交互作用等方面,旨在为未来研究提供新的视角和可能的治疗靶点,推动肝内胆管癌的早期诊断和有效治疗。Intrahepatic cholangiocarcinoma is a malignant tumor with an extremely poor prognosis,and its pathogenesis is complex and remains unclear.In recent years,more and more studies have focused on the role of bile-gut axis in the development and progression of intrahepatic cholangiocarcinoma.Bile-gut axis refers to the complex interaction between bile and gut microbiota,including bile salt metabolism,dynamic changes of microbiota,inflammatory response,and immune system regulation.This article elaborates on the potential mechanisms of bile-gut axis in intrahepatic cholangiocarcinoma,especially gut microbiota dysbiosis,abnormal bile salt metabolism,chronic inflammatory response,and immune system interaction,this article aims to provide new perspectives and possible therapeutic targets for future research and promote the early diagnosis and effective treatment of intrahepatic cholangiocarcinoma.

关 键 词：胆管上皮癌 胆-肠轴 胃肠道微生物组 胆盐代谢 炎症 

分 类 号：R73[医药卫生—肿瘤]