肝内胆管癌间质-免疫微环境内成分及其相互作用  

Components of tumor stroma-immune microenvironment and their interactions in intrahepatic cholangiocarcinoma

作　　者：张秋露 李卓 刘从容 郭丽梅 ZHANG Qiulu;LI Zhuo;LIU Congrong;GUO Limei(Department of Pathology,Peking University Third Hospital/Department of Pathology,Peking University Health Science Center,Beijing 100191,China;National Cancer Center/National Clinical Research Center for Cancer/Department of Pathology,Cancer Hospital of Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China)

机构地区：[1]北京大学第三医院病理科/北京大学医学部病理系,北京100191 [2]国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院病理科,北京100021

出　　处：《临床肝胆病杂志》2025年第3期594-600,共7页Journal of Clinical Hepatology

摘　　要：肝内胆管癌(ICC)是一种高度恶性的肝脏肿瘤,由于早期无明显症状并缺乏有效的治疗手段,患者5年生存率极低。肿瘤间质-免疫微环境(TSIME)是肿瘤发生与演进过程中局部所处的一个动态变化的复杂生态系统,由多种细胞成分和非细胞成分共同组成,在ICC的发生、增殖、侵袭与进展过程中起着重要的作用,在一定程度上也决定了ICC的异质性及恶性程度。本文就ICC-TSIME内的T淋巴细胞、B淋巴细胞、自然杀伤细胞、树突状细胞、中性粒细胞、巨噬细胞、髓源性抑制细胞等多种细胞成分,趋化因子、细胞因子等非细胞成分,以及其与肿瘤细胞间复杂多变的相互作用机制进行综述,同时对免疫细胞与肿瘤细胞的空间相互作用关系进行综述,以期为ICC的免疫治疗提供潜在的研究方向,为未来更高效、更精确的ICC治疗带来新思路。Intrahepatic cholangiocarcinoma(ICC)is a highly malignant liver tumor,and due to the absence of symptoms in its early stage and the lack of effective treatment measures,patients tend to have an extremely low 5-year survival rate.The tumor stroma-immune microenvironment(TSIME)is a complex ecosystem that changes dynamically during tumorigenesis and evolution and consists of a variety of cellular and non-cellular components,and it plays an important role in the development,proliferation,invasion,and progression of ICC and determines the heterogeneity and malignancy of ICC to a certain degree.This article reviews the cellular components(such as T cells,B cells,natural killer cells,dendritic cells,neutrophils,macrophages,myeloid-derived suppressor cells)and non-cellular components(such as chemokines and cytokines)within the ICC TSIME,as well as the complex mechanisms of interaction between these components,and it also reviews the spatial interactions between immune cells and tumor cells,in order to provide potential research directions for ICC immunotherapy and new ideas for the effective and precise treatment of ICC in the future.

关 键 词：胆管上皮癌 肿瘤微环境 淋巴细胞 

分 类 号：R73[医药卫生—肿瘤]