Glycoalkaloids:Structural diversity and pharmacological activities  

作　　者：Yuelin Jia Guiyang Xia Lingyan Wang Huan Xia Xiaohong Wei Sheng Lin 

机构地区：[1]Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing,China [2]Wuya Innovation College,Shenyang Pharmaceutical University,Shenyang,China [3]College of Pharmaceutical Sciences,Qinghai University for Nationalities,Xining,China [4]College of Eco-Environmental Engineering,Qinghai University,Xining,China

出　　处：《Guideline and Standard in Chinese Medicine》2024年第2期44-61,共18页中医规范与标准(英文)

基　　金：supported by the National Natural Science Foundation of China(No.82073978);the Fundamental Research Funds for the Central Universities(No.2023-JYBJBZD-048 and 2022-JYB-JBZR-015).

摘　　要：Glycoalkaloids(GAs)are a class of special secondary metabolites found in plants.Studies have found that they have a wide range of pharmacological activities,such as antiviral,antifungal,and anticancer properties,with significant potential for development and utilization value.At present,alkaloid glucosides mainly fall into 2 categories:indole alkaloid glucosides and steroid alkaloid glucosides.In addition,there are small amounts of quinolines,isoquinolines,isoguanines,and other alkaloids.At present,only a few of the GAs have been found,which is inconsistent with the diversity of alkaloids.In addition,only a few GAs have been isolated and identified.This paper reviews the natural alkaloid glycosides from the perspectives of structural classification and pharmacological activity.It analyzes the reasons for the limited number of isolated components and proposes a rational separation method based on the literature.To provide references for the separation,identification,and bioactivity of glycoalkaloids.

关 键 词：GLYCOALKALOIDS water-soluble extract separation methods 

分 类 号：O62[理学—有机化学]