阿尔茨海默病痴呆前阶段认知储备与认知功能的相关性研究  

The relationship between cognitive reserve and cognitive function in the pre-dementia stage of Alzheimer's disease

作　　者：李志 刘凤香 石林 包彩凤 史瑞仙 贾琪 梁芙茹[3] Zhi LI;Fengxiang LIU;Lin SHI;Caifeng BAO;Ruixian SHI;Qi JIA;Furu LIANG(Xing'an League People's Hospital,Ulanhot 137400,Inner Mongolia Autonomous Region,China;Dalat Banner People's Hospital,Ordos 014300,Inner Mongolia Autonomous Region,China;Baotou Central Hospital,Baotou 014040,Inner Mongolia Autonomous Region,China)

机构地区：[1]兴安盟人民医院,内蒙古乌兰浩特137400 [2]达拉特旗人民医院,内蒙古鄂尔多斯014300 [3]包头市中心医院,内蒙古包头014000

出　　处：《阿尔茨海默病及相关病杂志》2025年第2期92-97,103,共7页Chinese Journal of Alzheimer's Disease and Related Disorders

基　　金：北京师范大学认知神经科学与学习国家重点实验室开放性课题项目(CNLYB1702);内蒙古自治区神经系统疾病临床研究中心建设项目(2019P3084);内蒙古自治区包头市中心医院神经病学院士专家工作站资助项目(2017Y2001)。

摘　　要：目的:研究认知储备(cognitive reserve,CR)代理变量对阿尔茨海默病(Alzheimer's disease,AD)痴呆前阶段患者认知功能的影响。方法:选择25例正常对照者(normal control,NC)和45例轻度认知障碍(mild cognitive impairment,MCI)患者。所有入组患者行认知储备指数问卷(cognitive reserve index questionnaire,CRIq)调查,得出总分、教育、工作活动及休闲时间得分,同时完成认知功能量表评估。最后,对认知储备代理变量和认知功能量表各认知域评分进行相关分析和线性回归分析。结果:(1)总分数、教育、休闲时间与反映整体认知水平的简明精神状态量表(mini-mental state examination,MMSE)得分(r=0.506、P<0.001,r=0.398、P<0.001,r=0.448、P<0.001)和蒙特利尔认知评估量表(montreal cognitive assessment,MoCA)得分(r=0.492、P<0.001,r=0.353、P=0.002,r=0.403、P<0.001)均呈正相关。(2)教育与数字符号转换测验、听觉词语学习测验总分及延迟回忆和波士顿命名测验评分呈正相关(P均<0.05);工作活动与数字符号测验、听觉词语学习测验延迟记忆、数字广度正背测验呈正相关(P均<0.05);休闲时间与听觉词语学习测验总分及延迟回忆、数字广度正背测验、数字符号转换测验、动物词语流畅性和波士顿命名测验呈正相关(P均<0.05);总分数与听觉词语学习测验总分及延迟回忆、数字广度正背测验、动物词语流畅性测验、数字符号转换测验和数字广度倒背测验呈正相关(P均<0.05)。结论:(1) AD痴呆前阶段患者的综合认知储备与整体认知功能之间存在关联。(2)教育水平、休闲活动与综合认知、记忆力和语言能力均具有相关性,工作活动仅与综合认知和记忆力相关。Objective:To investigate the effect of cognitive reserve(CR)proxy variables on cognitive function in pre dementia patients with Alzheimer's disease(AD).Methods:25 normal controls(NC)and 45 patients with mild cognitive impairment(MCI)were selected.All enrolled patients received Cognitive Reserve Index questionnaire(CRIq)to obtain the total score,education,work activities and leisure time scores,and completed the cognitive function scale assessment.Finally,correlation analysis and linear regression analysis were carried out on the proxy variables of cognitive reserve and the scores of each cognitive domain of the cognitive function scale.Results:①Total score,education and leisure time were positively correlated with Mini-mental State Examination(MMSE)score(r=0.506,P<0.001,r=0.398,P<0.001,r=0.448,P<0.001)and Montreal Cognitive Assessment(MoCA)score(r=0.492,P<0.001,r=0.353,P=0.002,r=0.403,P<0.001)reflecting overall cognition.②Education and number symbol conversion test,auditory word learning test,delayed recall and Boston Naming test were positively correlated(both P<0.05);The work activity was positively correlated with the number symbol test,the auditory word learning test,the delayed memory,and the number span positive memory test(both P<0.05).Leisure time was positively correlated with the total score of auditory word learning test and delayed recall,number span test,number symbol conversion test,animal word fluency and Boston naming test(both P<0.05).The total score was positively correlated with the total score of auditory word learning test and delayed recall,number span forward memorization test,animal word fluency test,number symbol conversion test and number span backward memorization test(both P<0.05).Conclusion:①There is a correlation between comprehensive cognitive reserve and overall cognitive function in AD patients in the pre-dementia stage.②Education level and lifelong leisure activities are correlated with the comprehensive cognitive scale,memory and language ability,while occupational compl

关 键 词：轻度认知障碍 阿尔茨海默病 认知储备 认知功能 

分 类 号：R740[医药卫生—神经病学与精神病学]