阿尔茨海默病研究战略布局及近年项目资助  

Strategies of Alzheimer's disease and recent project funding

作　　者：邓桦 Hua DENG(Shanghai Library(Institute of Scientific and Technological Information of Shanghai),Shanghai 200031,China)

机构地区：[1]上海图书馆(上海科学技术情报研究所),上海200031

出　　处：《阿尔茨海默病及相关病杂志》2025年第2期104-108,126,共6页Chinese Journal of Alzheimer's Disease and Related Disorders

摘　　要：目的:全球正在应对阿尔茨海默病(AD),通过梳理部分国家战略计划与项目资助情况,系统了解不同国家针对AD预防与治疗的举措。方法:调研国家政策,利用知领全球科研项目库检索近年AD项目信息,通过计量与内容分析对检索项目展开分析。结果:现阶段,美国重点兴建具备不同职能的AD研究中心;欧洲研究侧重信号通路/调控与靶点发现;加拿大重视标志物与靶点发现;中国研究投入力度不断增加。结论:部分国家已对如何应对AD做出立法,信号通路/调控、靶点发现,药物研发是AD研究的主要内容,有效标志物筛选及科普传播是AD研究未来的发展趋势。Objective:Global has dealing with Alzheimer's disease.By sorting out major countries'strategic plans and project funding,we can learn systematically about the prevention and treatment of Alzheimer's disease in different countries.Methods:Research on policies,and the global scientific research project database was used to search for projects related to Alzheimer's disease.The retrieved projects were analyzed by a combination of measurement and content analysis.Results:At present,the United States has energetically built Alzheimer's disease research centers with different functions;Europe has focused on signaling pathways/regulation and discovering drug targets;Canada values biomarkers and drug targets;China has invested a lot as well.Conclusion:Some countries have made legislation on how to deal with AD.Signaling pathways/regulation,target discovery and drug development are the main contents of AD research,and effective marker screening and popular science dissemination are the future development trends of AD research.

关 键 词：阿尔茨海默病 药物靶点 成像 科研设施 经费资助 

分 类 号：G35[文化科学—情报学] R74[医药卫生—神经病学与精神病学]