miRNA介导的NLRP3炎性小体在阿尔茨海默病进展中的作用研究  

Role of the miRNA-mediated NLRP3 inflammasome in the progression of Alzheimer's disease

作　　者：陈肖杰 赵维纳 丁明璐 王万瑶 宋一丹 霍柯源 项子瀚 王建行 陈泠羽 刘兰涛 Xiaojie CHEN;Weina ZHAO;Minglu DING;Wanyao WANG;Yidan SONG;Keyuan HUO;Zihan XIANG;Jianhang WANG;Lingyu CHEN;Lantao LIU(MuDanJiang Medical University,Mudanjiang 157011,Heilongjiang,China;Hongqi Hospital Affiliated To MuDanJiang Medical University/Neurology,Mudanjiang 157009,Heilongjiang,China;Mudanjiang Collaborative Innovation Center for the Development and Application of Northern Medicinal Resources,Mudanjiang 157011,Heilongjiang,China)

机构地区：[1]牡丹江医科大学,黑龙江牡丹江157011 [2]牡丹江医科大学附属红旗医院/神经内科,黑龙江牡丹江157009 [3]牡丹江市北药资源开发与应用协同创新中心,黑龙江牡丹江157011

出　　处：《阿尔茨海默病及相关病杂志》2025年第2期120-126,共7页Chinese Journal of Alzheimer's Disease and Related Disorders

基　　金：黑龙江省自然科学基金项目(SS2023H005);黑龙江省省属高等学校基本科研费科研项目(2022-KYYWF-0662);牡丹江医学院附属红旗医院博士基金项目(2024-HQBS-12);牡丹江医学院研究生导师科研专项计划(YJSZX2022064)。

摘　　要：阿尔茨海默病(Alzheimer's disease,AD)作为一种神经变性疾病,其发病机制异常复杂,涉及多种生物学过程。近年来,微小RNA(miRNA)与核苷酸结合寡聚化结构域样受体含pyrin结构域蛋白3(nucleotide-binding oligomerization domain-like receptor pyrin domain-containing 3,NLRP3)炎性小体在AD发病过程中的作用日益受到关注。本文从研究背景和研究意义出发,综述了当前关于miRNA介导的NLRP3炎性小体在AD进展中的作用及机制。希望能为深入理解AD的发病机制和探索新的治疗方法提供有益参考和为临床AD的治疗带来新的突破。Alzheimer's disease(AD),as a neurodegenerative disease,has an abnormally complex pathogenesis and involves various biological processes.In recent years,the role of miRNA and NLRP3 inflammasome in AD,Which has been increasingly drawing attention,is becoming more and more significant.Based on the research background and significance,the article summarizes the current understanding of the role and mechanisms of miRNA-mediated NLRP3 inflammasome in the progression of AD.It is hoped that it may provide useful reference for deeply understanding the pathogenesis of AD and exploring new treatment methods as well as bring new breakthroughs for the therapy of AD.

关 键 词：微小RNA 神经炎症 NLRP3炎性小体 阿尔茨海默病 

分 类 号：R741[医药卫生—神经病学与精神病学]