细胞外囊泡在阿尔茨海默病中的研究进展  

Research Progress of extracellular vesicles in Alzheimer's disease

作　　者：代洁 李加梅 辛华[2] 卜亚丽 祝艳芳 姚舒馨 董丽华[2] Jie DAI;Jiamei LI;Hua XIN;Yali BU;Yanfang ZHU;Shuxin YAO;Lihua DONG(Jining Medical University College,Jining 272000,Shandong,China;Department of Neurology,Rizhao People's Hospital of Shandong Province,Rizhao 276800,Shandong,China;Shandong Second Medical University,Weifang 261000,Shandong,China)

机构地区：[1]济宁医学院,山东济宁272000 [2]日照市人民医院神经内科,山东日照276800 [3]山东第二医科大学,山东潍坊261000

出　　处：《阿尔茨海默病及相关病杂志》2025年第2期138-143,共6页Chinese Journal of Alzheimer's Disease and Related Disorders

摘　　要：细胞外囊泡(extracellular vesicles,EV)作为一种细胞释放的各种具有膜结构的囊泡结构统称,其内容物包括跨膜蛋白、脂质,细胞骨架结构蛋白、酶、转录因子、脱氧核糖核酸(deoxyribonucleic acid,DNA)和核糖核酸(ribonucleic acid,RNA)等物质,广泛存在于血液、脑脊液等体液中,EV可以促进细胞间联系,影响大脑的内稳态和功能,同时又可以促进阿尔茨海默病(Alzheimer’s disease,AD)等神经变性疾病的进展。从EV在AD中发生发展的作用、EV作为AD的生物标志物、EV用于AD的治疗等方面进行综述,为今后更早筛查及治疗AD提供借鉴。Extracellular vesicles are collectively referred to as various vesicle structures with membrane structures released by cells.Their contents include transmembrane proteins,lipids,cytoskeletal structural proteins,enzymes,transcription factors,DeoxyriboNucleic Acid,Ribonucleic Acid,and other substances.It is widely found in blood,cerebrospinal fluid and other body fluids.EV can promote intercellular communication,affect the homeostasis and function of the brain,and promote the progression of neurodegenerative diseases such as Alzheimer’s disease.This review discusses the research of EV in AD in this field.

关 键 词：细胞外囊泡 阿尔茨海默病 外泌体 

分 类 号：R741[医药卫生—神经病学与精神病学]