中性粒细胞胞外诱捕网在眼部疾病中的作用研究进展  

Research progress on the role of neutrophil extracellular traps in ocular diseases

作　　者：何梦梅 周健 He Mengmei;Zhou Jian(Department of Ophthalmology,Xijing Hospital,Air Force Medical University/Eye Institute of PLA,Xi'an 710032,Shaanxi Province,China)

机构地区：[1]空军军医大学西京医院眼科、全军眼科研究所,陕西省西安市710032

出　　处：《国际眼科杂志》2025年第4期611-614,共4页International Eye Science

基　　金：陕西省重点研发计划(No.2022SF-067);陕西省自然科学基金项目(No.2019JM-065)。

摘　　要：中性粒细胞胞外诱捕网(NETs)是一种由中性粒细胞排出的网状复合物,在抗菌防御中起着至关重要的作用。此外,NETs还会加剧与各种疾病相关的炎症反应,包括糖尿病、心血管疾病和自身免疫性疾病。目前,NETs在眼部疾病中的作用受到广泛关注。文章系统性总结了NETs的形成机制、在生理状态下维持眼内稳态平衡中的作用;同时,重点阐述了NETs在眼科疾病领域,包括干眼、角膜炎、葡萄膜炎、糖尿病视网膜病变、视网膜静脉阻塞、年龄相关性黄斑变性中的致病作用,强调了其作为眼部疾病治疗靶点的重要性及作为眼部疾病新的标志物的潜在应用价值。未来对NETs在眼部疾病中作用机制的深入研究,将为相关眼病的治疗提供更强的理论依据。Neutrophil extracellular traps(NETs)are net-like complexes released by neutrophils and play a crucial role in antimicrobial defense.In addition,NETs can exacerbate inflammatory responses associated with various diseases,including diabetes,cardiovascular diseases,and autoimmune diseases.Currently,the role of NETs in ocular diseases has received extensive attention.This article systematically summarizes the formation mechanism of NETs and their role in maintaining intraocular homeostasis under physiological conditions.At the same time,it focuses on elaborating the pathogenic role of NETs in the field of ophthalmic diseases,such as dry eye,keratitis,uveitis,diabetic retinopathy,retinal vein occlusion,and age-related macular degeneration,emphasizing the importance of NETs as therapeutic targets for ocular diseases and the potential application value as new markers for ocular diseases.Future in-depth research on the mechanism of NETs in ocular diseases will provide a stronger theoretical basis for the treatment of related eye diseases.

关 键 词：中性粒细胞胞外诱捕网 中性粒细胞 眼部疾病 炎症 

分 类 号：R73[医药卫生—肿瘤]