肠道巨噬细胞在炎症性肠病发病机制中的研究进展  

Research Progress of Intestinal Macrophages in Pathogenesis of Inflammatory Bowel Disease

作　　者：薄佳佳 郭婷婷[1] 申慧琴[2] BO Jiajia;GUO Tingting;SHEN Huiqin(Shanxi Medical University,Taiyuan,030000,China;Department of Gastroenterology,the Second Hospital of Shanxi Medical University,Taiyuan,030001,China)

机构地区：[1]山西医科大学,太原市030000 [2]山西医科大学第二医院消化内科,太原市030001

出　　处：《医学分子生物学杂志》2025年第2期205-210,共6页Journal of Medical Molecular Biology

摘　　要：炎症性肠病(inflammatory bowel disease,IBD)是一类由于炎症和免疫系统紊乱而导致的慢性复发性胃肠道炎症性疾病,其发病机制复杂,免疫系统攻击肠道的内壁,引起慢性炎症和组织损伤。作为一种典型的炎症性疾病,多种免疫细胞类型参与了IBD的发病过程,其中巨噬细胞被认为起着举足轻重的作用。肠道巨噬细胞是维持肠道免疫稳态的重要组成部分,限制肠道的炎症反应,对IBD的治疗具有重要意义。鉴于巨噬细胞可以协调炎症消退和组织修复,目前被认为是开发IBD新治疗方法的有吸引力的靶点。文章对肠道巨噬细胞的免疫调节作用在IBD中的研究进展进行了综述,为研究IBD的发病机制和临床治疗提供参考。Inflammatory bowel disease(IBD)is a class of chronic recurrent gastrointestinal inflammatory diseases caused by inflammation and immune system disorders.Its pathogenesis is complex,and the immune system attacks the lining of the intestine,causing chronic inflammation and tissue damage.As a typical inflammatory disease,multiple immune cell types are involved in the pathogenesis of IBD.Among them,macrophages are thought to play a pivotal role.Intestinal macrophages are an important part of maintaining intestinal immune homeostasis and inhibiting the inflammatory response,which is of great significance for the treatment of inflammatory bowel disease.Given that macrophages can coordinate inflammation resolution and tissue repair,they are currently considered an attractive target for developing new treatments for inflammatory bowel disease.This review summarizes the research progress of immunomodulatory role of intestinal macrophages in IBD,so as to provide reference for the research of pathogenesis and the clinical treatment of IBD.

关 键 词：炎症性肠病 巨噬细胞 肠道 稳态 

分 类 号：R574[医药卫生—消化系统]