血清MMP-9、MMP-26、TIMP-4与弥漫大B细胞淋巴瘤分期及预后的相关性  

Correlation of serum MMP-9,MMP-26,TIMP-4 with the staging and prognosis of diffuse large B-cell lymphoma

作　　者：陆文苑 崔颖超 周怡恬 罗安珥 陈韭铭 LU Wenyuan;CUI Yingchao;ZHOU Yitian;LUO Aner;CHEN Jiuming(Department of Laboratory Medicine,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China,201801)

机构地区：[1]上海交通大学医学院附属瑞金医院检验科,上海201801

出　　处：《分子诊断与治疗杂志》2025年第2期205-208,共4页Journal of Molecular Diagnostics and Therapy

基　　金：国家自然科学青年基金(82202581)。

摘　　要：目的研究血清基质金属蛋白酶-9(MMP-9)、基质金属蛋白酶-26(MMP-26)、基质金属蛋白酶抑制剂-4(TIMP-4)与弥漫大B细胞淋巴瘤(Diffuse large B celllymphoma,DLBCL)病理分期及预后的相关性。方法选取2021年1月1日至2022年4月1日于上海交通大学医学院附属瑞金医院治疗的75例DLBCL患者为研究组,另选取75例淋巴结反应性增生患者作为对照组,观察研究组与对照组及研究组不同分期、不同发病部位血清MMP-9、MMP-26及TIMP-4水平;采用Spearman分析DLBCL患者血清MMP-9、MMP-26与TIMP-4间的相关性;绘制Kaplan-Meier生存曲线,分析MMP-9、MMP-26、TIMP-4水平与DLBCL患者预后的关系。结果研究组血清MMP-9、MMP-26水平均高于对照组,血清TIMP-4水平均低于对照组,差异有统计学意义(P<0.05)。研究组Ⅰ~Ⅱ期患者血清MMP-9、MMP-26水平低于Ⅲ~Ⅳ期患者,血清TIMP-4水平高于Ⅲ~Ⅳ期患者,差异有统计学意义(P<0.05)。研究组不同发病部位患者血清MMP-9、MMP-26、TIMP-4水平比较差异均无统计学意义(P>0.05)。DLBCL患者血清MMP-9、MMP-26水平与TIMP-4水平呈负相关(P<0.05);血清MMP-9水平与MMP-26水平正相关(P<0.05)。MMP-9和MMP-26高表达、TIMP-4低表达组患者累积生存率低于其他组患者,差异具有统计学意义(P<0.05)。结论血清MMP-9、MMP-26及TIMP-4水平与DLBCL病理分期及患者预后密切相关,检测血清MMP-9、MMP-26及TIMP-4水平有助于明确DLBCL病理分期及评价患者预后。Objective To study the correlation between serum levels of matrix metalloproteinase 9(MMP-9),matrix metalloproteinase 26(MMP-26),tissue inhibitor of metalloproteinase-4(TIMP-4)and the pathological stage and prognosis of diffuse large B-cell lymphoma(DLBCL).Methods A total of 75 patients with DLBCL treated at Ruijin Hospital,Shanghai Jiao Tong University School of Medicine from January 1,2021 to April 1,2022 were selected as the study group.Another 20 patients with reactive lymph node hyperpla-sia were chosen as the control group.The serum levels of MMP-9,MMP-26,and TIMP-4 were observed in the study group at different stages and disease sites.Spearman's correlation analysis was used to examine the rela-tionship between serum MMP-9,MMP-26,and TIMP-4 levels in DLBCL patients.Kaplan-Meier survival curves to be drawn to assess the association between serum MMP-9,MMP-26,and TIMP-4 levels and the prog-nosis of DLBCL patients.Results The serum levels of MMP-9 and MMP-26 in the study group were higher than those in the control group,while the serum levels of TIMP-4 were lower.This difference was statistically significant(P<0.05).Additionally,the serum levels of MMP-9 and MMP-26 in patients with stageⅠtoⅡwere lower than those in patients with stageⅢtoⅣ,and the serum levels of TIMP-4 were higher in the latter group.This difference was statistically significant(P<0.05).There were no significant differences in serum levels of MMP-9,MMP-26,and TIMP-4 among patients with different disease sites(P>0.05).Furthermore,serum MMP-9 and MMP-26 levels in DLBCL patients were negatively correlated with TIMP-4 levels(P<0.05).I addi-tion,the serum MMP-26 level was positively correlated with the MMP-9 level(P<0.05).The cumulative sur-vival rate of patients with high expression of MMP-9 and MMP-26 and low expression of TIMP-4 was lower than that of other patients,and this difference was statistically significant(P<0.05).Conclusion Serum levels of MMP-9,MMP-26,and TIMP-4 are closely related to the pathological staging and prognosis of

关 键 词：弥漫大B细胞淋巴瘤 MMP-26 TIMP-4 MMP-9 

分 类 号：R733.1[医药卫生—肿瘤]