PSA、PCA3联合超声图像对前列腺癌穿刺活检的诊断价值  

The diagnostic value of PSA,PCA3 combined with ultrasound images in prostate cancer biopsy

作　　者：韩淑杰[1] 庞洪波 董艳霞[1] HAN Shujie;PANG Hongbo;DONG Yanxia(Ultrasound Medicine Department of Anyang People's Hospital,Anyang,Henan,China,455000)

机构地区：[1]河南省安阳市人民医院超声医学科,河南安阳455000

出　　处：《分子诊断与治疗杂志》2025年第2期370-373,共4页Journal of Molecular Diagnostics and Therapy

基　　金：安阳市科技计划项目(2018C01SF052)。

摘　　要：目的研究血清前列腺特异性抗原(PSA)、前列腺癌抗原3(PCA3)联合超声图像在前列腺癌穿刺活检诊断中的应用价值。方法选择2023年2月至2024年1月河南省安阳市人民医院收治的疑似前列腺癌患者109例作为研究对象,分析血清PSA、PCA3及超声图像情况,以穿刺活检病理结果为参照,评估不同检测指标在前列腺癌诊断中的应用价值。结果经病理确诊前列腺癌72例,非前列腺癌37例。前列腺癌患者的血清PSA、PCA3水平均显著高于非前列腺癌患者,差异有统计学意义(P<0.05);前列腺癌患者的超声图像前列腺非均匀性增大、结节边界不清晰、结节血流丰富异常检出率均显著高于非前列腺癌患者,差异有统计学意义(P<0.05)。血清PSA阳性共87例,血清PCA3阳性共76例,超声图像异常共95例。血清PSA阳性者、PCA3阳性者及超声图像异常者的前列腺癌检出率分别为41.24%、67.11%、70.53%,均显著低于血清PSA阳性、PCA3阳性联合超声图像异常者的前列腺癌检出率98.39%(P<0.05)。结论血清PSA、PCA3、超声图像在前列腺癌穿刺活检诊断中均具有应用价值,三者联合检测能够明显提高诊断价值。Objective To study the application value of serum prostate specific antigen(PSA)and prostate cell antigen3(PCA3)combined with ultrasound images in the diagnosis of prostate cancer biopsy.Methods 109 patients with suspected prostate cancer who were admitted to the hospital from February 2023 to January 2024 were selected as the research subjects.Their serum PSA,PCA3,and ultrasound images were analyzed.The pathological results of the biopsy were used as a reference to evaluate the application value of different detection indicators in diagnosing prostate cancer.Results There were 72 cases of prostate cancer and 37 cases of non-prostate cancer confirmed by pathology.The serum PSA and PCA3 levels in prostate cancer patients were significantly higher than those in non-prostate cancer patients(P<0.05).The detection rates of non-uniform enlargement of the prostate,unclear boundaries of nodules,and abnormal blood flow of nodules in ultrasound images of prostate cancer patients were significantly higher than those of non-prostate cancer patients(P<0.05).There were 87 cases of positive serum PSA,76 cases of positive serum PCA3,and 95 cases of abnormal ultrasound images.The detection rates of prostate cancer in patients with positive serum PSA,positive serum PCA3,and abnormal ultrasound images were 41.24%,67.11%and 70.53%,respectively,which were significantly lower than those in patients with serum PSA positive,PCA3 positive and abnormal ultrasound images(98.39%)(P<0.05).Conclusion Serum PSA,PCA3,and ultrasound images have valuable applications in diagnosing prostate cancer biopsies.Combining the detection of all three can significantly enhance the diagnostic accuracy.

关 键 词：前列腺癌 穿刺活检 前列腺特异性抗原 前列腺癌基因3 超声图像 

分 类 号：R737.25[医药卫生—肿瘤]