Amyloid deposits in prostate biopsy as an opportunity to diagnose early cardiac amyloidosis  

作　　者：María Cespón-Fernández Edgar JoséEscalona-Canal Jorge Sánchez-Ramos Sergio Raposeiras-Roubín Sámer Abdulkader-Sande Rafael JoséCobas-Paz Cristina Torreira-Banzas Emad Abu-Assi Susana Teijeira-Bautista Patricia Domínguez-Aristegui Pablo García-Pavía María Eugenia Escalona-Canal Enrique Cespón-Outeda JoséAntonio Ortiz-Rey 

机构地区：[1]Cardiology Department,Hospital UniversitarioÁlvaro Cunqueiro,Vigo,Spain [2]Galicia Sur Health Research Institute,Spain [3]Emergency Department,Hospital Universitario de Pontevedra,Spain [4]Ph.D.Program in Clinical Research in Medicine,University of Santiago de Compostela,Spain [5]Urology Department,Hospital UniversitarioÁlvaro Cunqueiro,Vigo,Spain [6]Pathology Department,Hospital UniversitarioÁlvaro Cunqueiro,Vigo,Spain [7]Laboratory Department,Hospital UniversitarioÁlvaro Cunqueiro,Vigo,Spain [8]Biobank of Galicia Sur Health Research Institute(IIS Galicia Sur).SERGAS-UVIGO,Vigo,Spain [9]Cardiology Department,Heart Failure and Inherited Cardiac Diseases Unit,Hospital Universitario Puerta de Hierro Majadahonda,Madrid,Spain [10]Pathology Department,Hospital Universitario de A Coruña,A Coruña,Spain

出　　处：《Journal of Geriatric Cardiology》2025年第1期169-177,共9页老年心脏病学杂志(英文版)

摘　　要：Background The diagnostic delay of cardiac amyloidosis(CA)is known to be substantially long.A prolonged time from symptoms onset to diagnosis negatively impacts quality of life and life expectancy of the affected patients.We aim to describe the role of the incidental finding of amyloid deposits in prostatic tissue as an early marker of CA.Methods A systematic cardiological evaluation,comprising ECG,echocardiogram and 99mTc-DPD scintigraphy,was offered to a cohort of 19 patients with incidental prostatic amyloidosis(PA)findings,propectively detected between 2014-2023,to assess cardiac involvement.Results The median age of the patients was 80.2 years(IQR:74.9-82.6 years).Histopathological study revealed amyloid deposits within the walls of small vessels(predominantly small arteries)in 18 patients and mainly in the stroma in the remaining case.All of them were immunohistochemically positive for transthyretin(ATTR)except one patient,with known myeloma,which was unconclusive fo ATTR.Clonal dyscrasia was excluded in the rest of the patients.Thirteen patients(68.4%)underwent all cardiological tests,4 patients(21.1%)underwent only ECG and echocardiographic evaluation and two patients(10.5%)refused to undergo any cardiological study.Among 13 individuals undergoing the complete evaluation,six patients were eventually diagnosed with CA(46.15%).All of them were asymptomatic from a cardiovascular point of view at the time of the prostate biopsy.Conclusion The finding of PA should prompt a complete cardiovascular examination,given the significant percentage of patients eventually diagnosed with early-stage CA.Multidisciplinary collaboration among different medical specialists must be encouraged,given the potential clinical impact of CA early diagnosis.

关 键 词：AMYLOID eventually finding 

分 类 号：R73[医药卫生—肿瘤]