HPV在男性泌尿生殖系统肿瘤中的研究进展  

HPV and male urinary system tumors:Progress in research

作　　者：徐石义 殷俊 张昆(综述) 尹皓立(审校) XU Shi-yi;YIN Jun;ZHANG Kun;YIN Hao-li(Chemotherapy Center for Outpatients,Department of Emergency,Yunnan Cancer Hospital,Kunming,Yunnan 650118,China;Department of Urology,Yunnan Cancer Hospital,Kunming,Yunnan 650118,China)

机构地区：[1]云南省肿瘤医院,急诊部/门诊化疗中心,云南昆明650118 [2]云南省肿瘤医院,泌尿外科一病区,云南昆明650118

出　　处：《中华男科学杂志》2025年第3期252-257,共6页National Journal of Andrology

基　　金：国家自然科学基金(82303654)。

摘　　要：人乳头瘤病毒(HPV)是一种致癌的DNA病毒,是最常见的性传播病毒,也是目前全球重大的公共卫生问题之一。尽管在男性中HPV感染现象较为普遍,但由于缺乏标准的HPV检测方式以及检测的复杂性,导致HPV检测在临床运用中仍难以实现。近来的研究中,探索了HPV与泌尿生殖系统肿瘤之间的关系,揭示了其受地理差异、组织学亚型和检测方法等因素的影响。进一步阐明HPV在泌尿生殖系统肿瘤发生、发展中的重要性。本综述探究了HPV和男性泌尿生殖系统肿瘤之间的复杂关系,归纳了其主要的致癌机制,为进一步了解HPV对泌尿生殖系统的影响提供参考。Human papilloma virus(HPV),a cancer-causing DNA virus,is a most common sexually transmitted virus and one of the major public health problems worldwide currently.Although HPV infection is relatively common in men,routine HPV detection is still difficult to be applied in clinical practice due to the lack of standard HPV detection methods and the complexity of its detection.Recent studies have explored the relationship between HPV and genitourinary tumors,revealed different results because of geographic differences,histological subtypes and detection methods,and stressed the importance of clarifying the role of HPV in the development and progression of genitourinary tumors.This review focuses on the complicated relationship of HPV with male genitourinary tumors,reveals its main carcinogenic mechanisms,and presents a new insight into the impact of HPV on the genitourinary system.

关 键 词：人乳头状瘤病毒 泌尿生殖系统肿瘤 疫苗 

分 类 号：R737[医药卫生—肿瘤]