黑色素瘤胃转移预后及影响因素  

Prognosis and Influencing Factors of Metastatic Melanoma of the Stomach

作　　者：张喜凤[1] 张艳玲[1] 向梅 魏丽[1] 王艳[1] 赵东丽[1] 毛玉焕 张维真[1] 梁宪斌[1] ZHANG Xifeng;ZHANG Yanling;XIANG Mei;WEI Li;WANG Yan;ZHAO Dongli;MAO Yuhuan;ZHANG Weizhen;LIANG Xianbin(Department of Medical Oncology,the Third People′s Hospitalof Zhengzhou,Zhengzhou 450000,China)

机构地区：[1]郑州市第三人民医院黑色素瘤肿瘤内科,河南郑州450000

出　　处：《皮肤科学通报》2025年第1期57-61,共5页Dermatology Bulletin

摘　　要：目的探讨黑色素瘤胃转移的临床特征及其与预后的相关性。方法对郑州市第三人民医院2017年10月—2024年8月收治的12例黑色素瘤胃转移患者临床资料进行回顾性分析,探讨胃转移出现时间、常见转移部位、影像学及胃镜下表现,以及基因突变、病理类型等因素对预后的影响。结果12例患者中,男6例,女6例,平均年龄为53.6岁,中位生存期为6.5个月,1年生存率为33%。因症状不典型,确诊率低,胃体是主要转移部位,影像学表现为胃壁局部增厚或结节样隆起,胃镜下典型特征为结节状隆起性病变及黏膜斑片状改变。胃转移多发生于一线治疗后,肢端型黑色素瘤、合并少见或罕见基因突变可能是黑色素瘤胃转移预后不良因素。结论黑色素瘤胃转移预后差,早诊断早治疗是提高生存率的关键,建议对高危患者尽早行胃镜检查,以改善预后。Objective To investigate the clinical features of metastatic melanoma of the stomach and its correlation with prognosis.Methods A retrospective analysis was conducted on 12 cases of metastatic melanoma of the stomach treated at the third people′s hospital of Zhengzhou from October 2017 to August 2024.To investigate the time of occurrence of stomach metastasis,common metastasis sites,imaging and gastroscopic manifestations.gene mutation,pathological type and other factors on the prognosis.Results Among the 12 patients,6 were males and 6 were females,average age of 53.6 years.The median survival time was 6.5 months,1-year survival rate of 33%.The diagnosis rate is low due to non-specific symptoms,stomach body was the main site of metastasis,The imaging findings were local thickening or nodular eminence of the gastric wall,The typical features of gastroscopy were nodular eminence and mucosal patchy changes.Gastric metastasis usually occurs after the first-line treatment,acral melanoma、combination of rare gene mutations may be adverse prognostic factors of metastatic melanoma of the stomach.Conclusion The metastatic melanoma of the stomach has poor prognosis,early diagnosis and treatment are critical to improve survival rates.It is recommended that with high risk patients undergo gastroscopy as soon as possible to improve the prognosis.

关 键 词：黑色素瘤 胃转移 预后 影响因素 

分 类 号：R739.6[医药卫生—肿瘤] R751[医药卫生—临床医学]