皮肤组织驻留记忆T细胞在黑色素瘤中的研究进展  

Research Progress of Skin Tissue Resident Memory T Cells in Melanoma

作　　者：关猛猛[1] 吴曹英[1] 康晓静[1] GUAN Mengmeng;WU Caoying;KANG Xiaojing(Department of Dermatology and Venereology,People′s Hospital of Xinjiang Uygur Autonomous Region,Xinjiang Clinical Research Center for Dermatology and Venereology,Xinjiang Key Laboratory of Dermatology Research,Urumqi 830001,China)

机构地区：[1]新疆维吾尔自治区人民医院皮肤性病科,新疆皮肤性病临床医学研究中心,新疆皮肤病研究重点实验室,新疆乌鲁木齐830001

出　　处：《皮肤科学通报》2025年第1期102-108,共7页Dermatology Bulletin

基　　金：新疆维吾尔自治区自然科学基金项目(2022D01C624);新疆维吾尔自治区“天山英才”培养计划(2022TSYCLJ0025)。

摘　　要：组织驻留记忆T细胞(T RM)通过表达整合素CD103、CD49a或C型凝集素CD69和免疫检查点受体,使其在组织中驻留,并发挥抗肿瘤作用。在抗肿瘤免疫的初始阶段,它们维持免疫平衡并保护免受肿瘤细胞的攻击和原发性黑色素瘤的形成。在转移性环境中,它们是免疫检查点抑制(ICI)的主要靶细胞群,因为它们高度表达抑制性检查点分子,如PD-1,CTLA-4或LAG-3。本文将围绕T RM的定义、分类分型、来源与分化、组织驻留性、调控机制、在黑色素瘤免疫治疗中疗效预测价值和预后价值进行综述。Tissue-resident memory T cell(T RM)can stay in tissues and play an anti-tumor role by expressing integrin CD103,CD49a or type C lectin CD69 and immune checkpoint receptor.In the initial stage of anti-tumor immunity,they maintain immune balance and protect against the attack of tumor cells and the formation of primary melanoma.In metastatic environment,they are the main target cell groups for immune checkpoint inhibition(ICI)because they express high levels of inhibitory checkpoint molecules,such as PD-1,CTLA-4 or LAG-3.This review focuses on the definition,classification,origin,differentiation,tissue persistence,regulatory mechanisms,and the predictive and prognostic value of TRM in melanoma immunotherapy.

关 键 词：黑色素瘤 组织驻留记忆T细胞 肿瘤微环境 免疫疗法 

分 类 号：R739.5[医药卫生—肿瘤] R751[医药卫生—临床医学]