血清sCD14联合sCD30对白血病患儿合并肺部真菌感染的诊断价值  

The diagnostic value of serum sCD14 combined with sCD30 in pediatric leukemia patients with pulmonary fungal infection

作　　者：雷珂[1] 陈栋 安沛欣 罗改莹 LEI Ke;CHEN Dong;AN Peixin;LUO Gaiying(Department of Clinical Laboratory,the Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710004,China;Department of Clinical Laboratory,Xi'an No.5 Hospital,Xi'an 710004,China)

机构地区：[1]西安交通大学第二附属医院检验科,西安710004 [2]西安市第五医院检验科,西安710004

出　　处：《国际免疫学杂志》2024年第6期676-682,共7页International Journal of Immunology

摘　　要：目的探究血清可溶性白细胞分化抗原(soluble leukocyte differentiation antigen,sCD)14联合sCD30对白血病患儿合并肺部真菌感染的诊断价值。方法选取2021年3月至2023年12月西安交通大学第二附属医院108例白血病合并肺部真菌感染患儿设为合并组,根据病情严重程度分为轻中度(88例)、重度(20例)。另选取同时期本院就诊的白血病患儿72例和健康患儿50例,分别设为白血病组和对照组。比较不同组别的实验室指标、血清sCD14及sCD30水平,采用Logistic分析白血病合并肺部真菌感染的影响因素并构建列线图,并利用Pearson分析相关指标的相关性。构建受试者工作特征曲线分析白血病合并肺部真菌感染的诊断效能。结果对照组、白血病组及合并组WBC、C反应蛋白(c-reactive protein,CRP)、降钙素原(procalcitonin,PCT)、白细胞介素1β(interleukin,IL-1β)、sCD14、sCD30水平差异有统计学意义[×10^(9)/L:(7.09±0.65)比(8.34±0.71)比(9.73±0.87);mg/L:(6.12±0.48)比(8.09±0.57)比(10.89±0.88);ng/L:(0.72±0.18)比(4.45±0.22)比(5.37±0.31);pg/L:(1.23±0.18)比(6.57±0.46)比(7.87±0.55);μg/mL:(4.21±0.24)比(9.38±0.79)比(10.21±0.88);ng/mL:(3.15±0.18)比(7.35±0.52)比(9.17±0.62),F值分别为209.21、873.72、5591.26、3565.48、1123.59、2271.13,P值均<0.05]。轻中度组的WBC、CRP、PCT、IL-1β、sCD14及sCD30水平低于重度组[×10^(9)/L:(7.89±0.65)比(9.54±0.77);mg/L:(8.12±0.78)比(11.09±0.91);ng/L:(4.32±0.22)比(5.45±0.32);pg/L:(6.13±0.51)比(7.57±0.66);μg/mL:(9.35±0.87)比(10.38±0.93);ng/mL:(7.59±0.45)比(9.21±0.88),t值分别为8.89、13.51、15.01、9.16、4.52、8.00,P值均<0.05]。Logistic分析表明,WBC、CRP、PCT、IL-1β、sCD14及sCD30是白血病合并肺部真菌感染的影响因素(P<0.05)。Pearson分析显示,患者的WBC、CRP、PCT、IL-1β、sCD14及sCD30与白血病合并肺部真菌感染的病情严重程度呈正相关(P<0.05)。受试者工作特征曲线结果表明sCD14及sCD30联�Objective To explore the diagnostic value of serum soluble leukocyte differentiation antigen(sCD)14 combined with sCD30 in pediatric leukemia patients with pulmonary fungal infection.Methods Total of 108 pediatric patients with leukemia complicated by pulmonary fungal infection admitted to the Second Affiliated Hospital of Xi'an Jiaotong University from March 2021 to December 2023 and concurrent pulmonary fungal infection were enrolled and categorized as the combined group,further divided based on the severity of their condition into mild to moderate(88 cases)and severe(20 cases)subgroups.Additionally,72 leukemia patients without fungal infection and 50 healthy children were selected during the same period,designated as the leukemia group and the control group,respectively.Laboratory indicators,serum sCD14,and sCD30 levels were compared across the different groups.Logistic regression was utilized to analyze the factors influencing leukemia combined with pulmonary fungal infection,and a nomogram was constructed.Pearson's analysis was employed to explore the correlation between various indicators and the severity of the disease.The diagnostic efficiency for pulmonary fungal infection in leukemia was assessed using the Receiver operating characteristic(ROC)curve.Results The comparison of WBC count,c-reactive protein(CRP),procalcitonin(PCT),interleukin-1β(IL-1β),sCD14,and sCD30 among the control group,leukemia group,and combined group showed statistically significant differences[×10^(9)/L:(7.09±0.65)vs(8.34±0.71)vs(9.73±0.87);mg/L:(6.12±0.48)vs(8.09±0.57)vs(10.89±0.88);ng/L:(0.72±0.18)vs(4.45±0.22)vs(5.37±0.31);pg/L:(1.23±0.18)vs(6.57±0.46)vs(7.87±0.55);μg/mL:(4.21±0.24)vs(9.38±0.79)vs(10.21±0.88);ng/mL:(3.15±0.18)vs(7.35±0.52)vs(9.17±0.62),F values were 209.21,873.72,5591.26,3565.48,1123.59,2271.13,respectively,all P values<0.05].The WBC,CRP,PCT,IL-1β,sCD14,and sCD30 levels in the mild-to-moderate group were lower than those in the severe group[×10^(9)/L:(7.89±0.65)vs(9.54±0.77);mg/L:(8.12�

关 键 词：血清可溶性白细胞分化抗原14 血清可溶性白细胞分化抗原30 白血病 肺部真菌感染 

分 类 号：R733.7[医药卫生—肿瘤] R725.1[医药卫生—临床医学]