Eph家族受体信号转导途径及其在感染性疾病中的研究进展  

Research progress of Eph/ephrin signaling transduction pathway in infectious diseases

作　　者：彭文涛 朱国强 华佳佳 李永华[2] PENG Wentao;ZHU Guoqiang;HUA Jiajia;LI Yonghua(School of Clinical Medicine,Jining Medical University,Jining 272067,China;Department of Ophthalmology,Affiliated Hospital of Jining Medical University,Jining 272029,China)

机构地区：[1]济宁医学院临床医学院,济宁272067 [2]济宁医学院附属医院眼科,济宁272029

出　　处：《国际免疫学杂志》2024年第6期683-688,共6页International Journal of Immunology

基　　金：国家自然科学基金项目(81300730);山东省自然科学基金(ZR2020QH149)。

摘　　要：促红细胞生成素肝细胞激酶(erythropoietin-producing hepatocellular receptor,Eph)受体是酪氨酸激酶受体中最大的一个家族,Eph受体及其膜锚定配体Ephrin介导的信号传导依赖于细胞与细胞间的直接接触,同时由于其具有受体-配体复合物的结构特点及其独特的相互作用模式,因而可与多种微生物细胞表面的病原相关分子模式相结合,通过不同的信号转导途径,进而在多种感染性疾病的发生、发展中发挥重要作用,具有广泛的临床研究价值。文章就Eph家族受体信号转导途径在细菌、真菌、病毒、寄生虫等多种感染性疾病中的调控机制展开了综述,为其在感染性疾病相关的基础研究、临床应用等方面提供理论依据。Erythropoietin-producing hepatocellular receptor(Eph)receptors are the most prominent family of receptor tyrosine kinases,and the signaling mediated by Eph receptors and their membrane-anchored ligand,Ephrin,depends on direct cell-to-cell contact.Meanwhile,due to their structural features of receptor-ligand complexes and unique interaction patterns,they can bind to pathogen-associated molecular patterns on the surface of various microbial cells and play an important role in developing various infectious diseases through different signaling.The Eph family of receptors has a wide range of clinical research value because of its structural characteristics and unique interaction patterns.This review focuses on the regulation mechanism of the Eph/ephrin signaling transduction pathway in bacteria,fungi,viruses,parasites,and other infectious diseases and provides a theoretical basis for their basic research and clinical application in infectious diseases.

关 键 词：促红细胞生成素肝细胞激酶 病原微生物 病原相关分子模式 信号转导通路 感染性疾病 

分 类 号：R73[医药卫生—肿瘤]