新型冠状病毒感染的神经后遗症:共同的病理机制能否揭示阿尔茨海默病的进展?  

Neurological sequelae of COVID-19: can shared pathological mechanismsreveal the progression of Alzheimer's disease?

作　　者：宋振硕 肖卫忠[2] SONG Zhenshuo;XIAO Weizhong(Department of General Practice,Third Clinical Medical College of Peking University,Beijing 100191,China;不详)

机构地区：[1]北京大学第三临床医学院全科医学科,北京100191 [2]北京大学第三医院神经内科,北京100191

出　　处：《中国临床研究》2025年第3期383-388,共6页Chinese Journal of Clinical Research

基　　金：全国医学专业学位研究生教育指导会员会全科医学教育教学研究课题(B-YXGP20210201-01)。

摘　　要：新型冠状病毒感染(COVID-19)会对神经系统产生显著影响,特别是在长期神经炎症、血脑屏障损伤、小胶质细胞激活等方面,这些改变与阿尔茨海默病(AD)的病理特征有重叠和相似之处。本文综述国内外关于COVID-19影响神经系统的病理生理过程以及与AD的发病机制相关的研究,并进一步讨论COVID-19与AD之间可能存在的共同机制,通过深入探讨这些机制,以期为理解COVID-19对神经系统的长期影响以及AD的发病机制提供新的视角,并为未来的预防与治疗策略提供参考。Coronavirus disease 2019(COVID-19)has significant effects on the nervous system,particularly in terms of long-term neuroinflammation,blood-brain barrier disruption,and microglial activation.These changes share overlaps and similarities with the pathological features of Alzheimer's disease(AD).This review summarizes recent domestic and international research on the pathophysiological processes through which COVID-19 affects the nervous system,and the mechanisms underlying AD.It further explores the potential common mechanisms between COVID-19 and AD,aiming to provide new insights into the long-term neurological impacts of COVID-19 and inform future prevention and treatment strategies.

关 键 词：新型冠状病毒感染 阿尔茨海默病 神经后遗症 神经炎症 血管紧张素转化酶2 载脂蛋白E4 

分 类 号：R741.02[医药卫生—神经病学与精神病学]