肿瘤细胞与神经信号在神经内分泌癌转移中的串扰作用:基于通讯劫持的视角  

Crosstalk between Tumor Cells and Neural Signals in Neuroendocrine Carcinoma Metastasis:Communication Hijacking Based Perspective

作　　者：宋淑萍 王心怡 周锶琪 成旭晨 林潍轩 王永炫 孙艳芹 Shuping SONG;Xinyi WANG;Siqi ZHOU;Xuchen CHENG;Weixuan LIN;Yongxuan WANG;Yanqin SUN(Department of Cancer Center,The Affiliated Dongguan Songshan Lake Central Hospital of Guangdong Medical University,Dongguan 523808,China;Department of Pathology,Guangdong Medical University,Zhanjiang 524000,China;The First Clinical Medical College,Guangdong Medical University,Zhanjiang 524000,China)

机构地区：[1]广东医科大学附属东莞松山湖中心医院肿瘤中心,东莞523808 [2]广东医科大学病理学系,湛江524000 [3]广东医科大学第一临床医学院,湛江524000

出　　处：《中国肺癌杂志》2025年第2期138-145,共8页Chinese Journal of Lung Cancer

基　　金：国家自然科学基金项目(No.81702285);广东省基础与应用基础研究基金项目(No.2022A1515012190);湛江市科技发展专项资金竞争性分配项目(No.2022A01018);大学生创新创业训练计划项目(No.S202410571113);广东医科大学松山湖医工融合创新中心专项项目(No.4SG22312P)资助。

摘　　要：神经内分泌癌(neuroendocrine carcinoma, NEC)为一类起源于神经内分泌细胞的恶性肿瘤。由于NEC细胞兼具神经细胞和内分泌细胞的特性,在肿瘤转移过程中可通过多种机制劫持神经元信号传导并动态调节神经元谱系标志物的表达,从而形成有利于肿瘤生长与转移的微环境。另一方面,肿瘤微环境的变化反过来也会增强神经元与肿瘤细胞的相互作用,最终协同促进NEC转移的发生。本综述介绍了癌症神经科学领域的研究进展,揭示了NEC中的神经元谱系标志物,通过介导肿瘤细胞与神经系统之间发生串扰、双向交流以及协同作用,促进肿瘤扩散转移。因此,肿瘤神经科学领域的最新研究成果,丰富了我们对肿瘤转移生物学机制的认识,为深入理解肿瘤转移,特别是脑转移的复杂生物学过程,开辟了新的研究方向。本文就肿瘤细胞与神经信号在NEC转移中的串扰作用作一综述。Neuroendocrine carcinoma(NEC)represents a category of malignant tumors originating from neuroen-docrine cells.Given that NEC cells exhibit characteristics of both neural and endocrine cells,they can hijack neuronal signaling pathways and dynamically regulate the expression of neuronal lineage markers during tumor metastasis,thereby constructing a microenvironment conducive to tumor growth and metastasis.Conversely,alterations in the tumor microenvironment can enhance the interactions between neurons and tumor cells,ultimately synergistically promoting the metastasis of NEC.This review highlights recent advancements in the field of cancer neuroscience,uncovering neuronal lineage markers in NEC that facilitate tumor dissemination through mediating crosstalk,bidirectional communication,and synergistic interactions between tumor cells and the nervous system.Consequently,the latest findings in tumor neuroscience have enriched our understanding of the biological mechanisms underlying tumor metastasis,opening new research avenues for a deeper comprehension of the complex biological processes involved in tumor metastasis,particularly brain metastasis.This review provides a comprehensive review of the crosstalk between tumor cells and neural signaling in the metastasis of NEC.

关 键 词：癌症神经科学 肿瘤转移 神经内分泌癌 串扰作用 通讯劫持 

分 类 号：R73[医药卫生—肿瘤]