糖尿病性白内障患者房水SDF-1、MCP-1及sCD44水平变化及其临床意义  

Changes and clinical significance of SDF-1,MCP-1 and sCD44 levels in aqueous humor of patients with diabetic cataract

作　　者：曲晓瑜 朱红娜[1] 苏安乐 陆慧琴[1] 王昞 QU Xiaoyu;ZHU Hongna;SU Anle;LU Huiqin;WANG Bing(Department of Ophthalmology,Xi′an First Hospital,Xi′an,Shaanxi 710002,China)

机构地区：[1]西安市第一医院眼科,陕西西安710002

出　　处：《国际检验医学杂志》2025年第6期694-697,703,共5页International Journal of Laboratory Medicine

基　　金：陕西省重点研发计划项目(2022SF-312)。

摘　　要：目的分析糖尿病性白内障(DC)患者房水基质细胞衍生因子-1(SDF-1)、巨噬细胞趋化蛋白-1(MCP-1)及可溶性黏附分子CD44(sCD44)水平变化及其临床意义。方法选取2021年1月至2023年1月该院收治的80例DC患者为DC组,同期40例单纯性白内障患者为年龄相关性白内障组。根据白内障分期将DC患者分为A组(初发期,32例)、B组(膨胀期,26例)及C组(成熟期及过熟期,22例)。根据DC患者治疗后有无黄斑水肿发生分为发生组(20例)、未发生组(60例)。采用酶联免疫吸附试验检测各组SDF-1、MCP-1及sCD44水平变化,采用受试者工作特征曲线及曲线下面积(AUC)分析房水SDF-1、MCP-1及sCD44水平诊断DC的价值。结果DC组房水SDF-1、MCP-1及sCD44水平高于年龄相关性白内障组(P<0.05),A、B、C组SDF-1、MCP-1及sCD44水平依次升高(P<0.05),发生组MCP-1水平高于未发生组(P<0.05)。房水MCP-1、sCD44及SDF-1联合诊断DC的AUC为0.869,诊断效能较好。结论房水SDF-1、MCP-1及sCD44水平变化与DC患者白内障分期有关,对于这三项指标,尤其是房水MCP-1,进行动态监测有利于判断DC患者病情和预后。Objective To analyze the changes and clinical significance of aqueous humor stromal cell-derived factor-1(SDF-1),macrophage chemoattractant protein-1(MCP-1)and soluble adhesion molecule CD44(sCD44)in patients with diabetic cataract(DC).Methods A total of 80 patients with DC admitted to the hospital from January 2021 to January 2023 were selected as the DC group,and 40 patients with simple cataract during the same period were selected as the age-related cataract group.According to the stage of cataract,DC patients were divided into group A(incipient stage,32 cases),group B(intumescent stage,26 cases)and group C(mature stage and over mature stage,22 cases).According to the presence or absence of macular edema after treatment,the patients were divided into occurrence group(20 cases)and non-occurrence group(60 cases).The levels of SDF-1,MCP-1 and sCD44 in each group were detected by enzyme-linked immunosorbent assay.The receiver operating characteristic curve and area under the curve(AUC)were used to analyze the value of SDF-1,MCP-1 and sCD44 levels in the diagnosis of DC.Results The levels of SDF-1,MCP-1 and sCD44 in the DC group were higher than those in the age-related cataract group(P<0.05),and the levels of SDF-1,MCP-1 and sCD44 in the A,B and C groups increased sequentially(P<0.05).The level of MCP-1 in the occurrence group was higher than that in the non-occurrence group(P<0.05).The AUC of MCP-1,sCD44 and SDF-1 in the diagnosis of DC was 0.869,and the diagnostic efficiency was better.Conclusion The changes of aqueous SDF-1,MCP-1 and sCD44 levels are related to the stage of cataract in DC patients.Dynamic monitoring of these three indexes,especially MCP-1,is helpful to judge the condition and prognosis of DC patients.

关 键 词：糖尿病性白内障 房水 基质细胞衍生因子-1 巨噬细胞趋化蛋白-1 可溶性黏附分子CD44 

分 类 号：R770.4[医药卫生—眼科]