细胞角蛋白19片段、SCC、NSE联合纤维蛋白原对肺癌病理类型及淋巴结转移的诊断价值  

Diagnostic value of CYFRA21-1,SCC,NSE combined with fibrinogen in pathological type and lymph node metastasis of lung cancer

作　　者：董斌 张莉 韩凌飞 薛炜 DONG Bin;ZHANG Li;HAN Lingfei;XUE Wei(Department of Clinical Laboratory,Deyu Medical Maanshan General Hospital,Maanshan,Anhui 243000,China;Department of Clinical Laboratory,Maanshan Clinical Testing Center,Maanshan,Anhui 243000,China)

机构地区：[1]德驭医疗马鞍山总医院检验科,安徽马鞍山243000 [2]马鞍山市临床检验中心检验科,安徽马鞍山243000

出　　处：《国际检验医学杂志》2025年第6期728-732,737,共6页International Journal of Laboratory Medicine

基　　金：马鞍山市科技计划项目(YL-2022-36)。

摘　　要：目的探讨细胞角蛋白19片段(CYFRA21-1)、鳞状上皮细胞癌抗原(SCC)、神经元特异性烯醇化酶(NSE)联合纤维蛋白原(FIB)对肺癌病理类型及淋巴结转移的诊断价值。方法选取2022年9月至2024年3月德驭医疗马鞍山总医院收治的58例肺癌患者为肺癌组,其中肺鳞癌14例、肺腺癌36例、小细胞肺癌8例,淋巴结转移39例、淋巴结未转移19例。另选取同期于德驭医疗马鞍山总医院就诊的肺部良性病变患者45例为对照组,比较两组CYFRA21-1、SCC、NSE、FIB水平,采用受试者工作特征(ROC)曲线分析CYFRA21-1、SCC、NSE联合FIB对肺癌病理类型及淋巴结转移的诊断价值。结果肺癌组CYFRA21-1、NSE、SCC、FIB水平均高于对照组(P<0.05)。不同病理类型肺癌患者CYFRA21-1、NSE、SCC、FIB水平比较,差异均有统计学意义(P<0.05),小细胞肺癌患者FIB、NSE水平均高于肺鳞癌和肺腺癌患者(P<0.05),肺鳞癌患者CYFRA21-1、SCC水平高于肺腺癌、小细胞肺癌患者(P<0.05)。淋巴结转移患者CYFRA21-1、NSE、SCC、FIB水平均高于淋巴结未转移患者(P<0.05)。ROC曲线分析结果显示,CYFRA21-1、NSE、SCC、FIB单独及联合检测诊断肺癌的曲线下面积(AUC)分别为0.795、0.620、0.672、0.757、0.812,上述指标联合检测诊断肺癌、肺腺癌、肺鳞癌、小细胞肺癌、淋巴结转移的AUC分别为0.812、0.837、0.786、0.922、0.875。结论CYFRA21-1、SCC、NSE联合FIB可以提高肺癌病理类型及淋巴结转移的诊断价值。Objective To investigate the diagnostic value of cytokeratin 19 fragment(CYFRA21-1),squamous cell carcinoma antigen(SCC),neuron-specific enolase(NSE)combined with fibrinogen(FIB)in pathological type and lymph node metastasis of lung cancer.Methods A total of lung cancer patients admitted to Deyu Medical Maanshan General Hospital from September 2022 to March 2024 were selected as the lung cancer group,including 14 cases of lung squamous cell carcinoma,36 cases of lung adenocarcinoma,8 cases of small cell lung cancer,39 cases of lymph node metastasis and 19 cases of no lymph node metastasis.In addition,45 patients with benign pulmonary lesions in Deyu Medical Ma′anshan General Hospital during the same period were selected as the control group.The levels of CYFRA21-1,SCC,NSE and FIB were compared between the two groups.The receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of CYFRA21-1,SCC,NSE combined with FIB for pathological type and lymph node metastasis of lung cancer.Results The levels of CYFRA21-1,NSE,SCC and FIB in lung cancer group were higher than those in control group(P<0.05).There were statistically significant differences in CYFRA21-1,NSE,SCC and FIB levels in patients with different pathological types of lung cancer(P<0.05).The levels of FIB and NSE levels in patients with small cell lung cancer were higher than those in patients with lung squamous cell carcinoma and lung adenocarcinoma.The levels of CYFRA21-1 and SCC in patients with lung squamous cell carcinoma were higher than those in patients with lung adenocarcinoma and small cell lung cancer(P<0.05).The levels of CYFRA21-1,NSE,SCC and FIB in patients with lymph node metastasis were higher than those in patients without lymph node metastasis(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of CYFRA21-1,NSE,SCC and FIB alone and in combination were 0.795,0.620,0.672,0.757 and 0.812,respectively.The AUC of combined detection in the diagnosis of lung cancer,lung adenocarcinoma,lung squamous cel

关 键 词：细胞角蛋白19片段 鳞状上皮细胞癌抗原 神经元特异性烯醇化酶 纤维蛋白原 肺癌病理类型 淋巴结转移 

分 类 号：R734.2[医药卫生—肿瘤]