社会经济地位对胃肠道恶性肿瘤患者生活质量的影响研究  

The association of socioeconomic status with quality of life in gastrointestinal cancer patients

作　　者：郑西特 李全美 刘芬 Zheng Xite;Li Quanmei;Liu Fen(Department of Epidemiology and Health Statistics,School of Public Health,Capital Medical University,Beijing 100069,China)

机构地区：[1]首都医科大学公共卫生学院流行病与卫生统计学系,北京100069

出　　处：《肿瘤代谢与营养电子杂志》2025年第1期115-122,共8页Electronic Journal of Metabolism and Nutrition of Cancer

摘　　要：目的了解中国胃肠道恶性肿瘤(GIC)患者的生活质量现状,探讨总体社会经济地位(SES)与生活质量的关联。方法依托常见恶性肿瘤患者营养状况与临床结局相关性研究(INSCOC),选取2013年10月至2023年10月的GIC患者作为研究对象。使用欧洲癌症研究与治疗组织生活质量问卷(EORTC QLQ-C30)进行生活质量评估,采用线性回归模型分析SES和生活质量的关联。结果共纳入12006例GIC患者,生活质量总体评分平均(86.77±12.04)分。多重线性回归分析结果显示,GIC患者的总体SES与生活质量总分(b=1.89,P<0.001;b=1.94,P<0.01)、功能领域总分(b=14.90,P<0.001;b=17.75,P<0.001)、总体健康状况/生活质量总分(b=3.21,P<0.001;b=4.19,P<0.001)呈正相关,与症状领域和单一条目总分(b=-21.01,P<0.001;b=-26.28,P<0.001)呈负相关。3个SES指标与生活质量总体评分、功能领域、总体健康状况/生活质量以及症状领域和单一条目总分的关联与总体SES相似,但其中就业情况与总体健康状况/生活质量的关联并不显著。结论中国GIC患者的生活质量还有待改善,应加强GIC患者的社会经济支持,提高其生活质量。Objective To examine the quality of life(QoL)among patients with gastrointestinal cancer(GIC)in China and to explore the association between overall socioeconomic status(SES)and QoLMethod Data were derived from the Investigation on Nutrition Status and Its Clinical Outcome of Common Cancers(INSCOC).Patients with GIC from October 2013 to October 2023 were selected.The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30(EORTC QLQ-C30)was used for QoL assessment.A linear regression model was applied to analyze the relationship between SES and QoL.Result A total of 12,006 GICpatients were included,with a mean QoL summary score of 86.77±12.04.Multiple linear regression analysis showed that overall SES was positively correlated with the QoL summary score(b=1.89,P<0.001;b=1.94,P<0.01),functional scale(b=14.90,P<0.001;b=17.75,P<0.001),and global health status/QoL(b=3.21,P<0.001;b=4.19,P<0.001),and negatively correlated with symptom scale/item scores(b=-21.01,P<0.001;b=-26.28,P<0.001).The associations between the three SES indicators and QoL summary score,functional scale,global health status/QoL,and symptom scale/item were similar to the overall SES.However,employment status was not significantly associated with global health status/QoL.Conclusion The QoL of patients with GIC in China needs improvement.Social and economic support should be strengthened to enhance their quality of life.

关 键 词：社会经济地位 生活质量 胃肠道恶性肿瘤 观察性研究 欧洲癌症研究与治疗组织生活质量问卷 多重线性回归 信度 效度 

分 类 号：R73[医药卫生—肿瘤]