竞争性内源RNA调控网络相关正反馈环路在胃癌中的研究进展  

Research progress of ceRNA regulatory network related positive feedback loop in gastric cancer

作　　者：陈昱豪 韩竞翔 高琳娜 高辉阳 姚添 黄河[1,2] Chen Yuhao;Han Jingxiang;Gao Linna;Gao Huiyang;Yao Tian;Huang He(The First Clinical Medical College,Shanxi Medical Unitersity,Taiyuan 030001,Shanxi,China;Department of Gastrointestinal Surgery,the First Hospital of Shanxi Medical University,Taiyuan 030001,Shanxi,China)

机构地区：[1]山西医科大学第一临床医学院,山西太原030001 [2]山西医科大学第一医院胃肠外科,山西太原030001

出　　处：《肿瘤代谢与营养电子杂志》2025年第1期136-142,共7页Electronic Journal of Metabolism and Nutrition of Cancer

基　　金：山西省基础研究计划项目(202303021211202)。

摘　　要：胃癌严重影响人类健康,已经成为全球关注的重大健康问题,在其复杂的发病机制中,基因调控网络扮演着重要角色。其中,竞争性内源RNA(ceRNA)调控网络又是一个重要的研究领域。这个网络涉及多种RNA分子之间的相互作用,包括mRNA、miRNA、lncRNA和circRNA等,它们通过复杂的调控机制精确控制基因表达,从而影响胃癌的发生、发展。正反馈环路是生物体内中不可或缺的信号转导机制,它通过循环增强初始信号来加速或放大特定的生物学过程,不仅在细胞生长、发育和应对各种生理、病理刺激中起到至关重要的作用,而且可以通过多方面参与肿瘤的发生、发展,如促进肿瘤细胞的增殖和侵袭、改变肿瘤微环境和增加肿瘤细胞化疗抗性。在ceRNA调控网络中也存在着正反馈环路,这些正反馈环路通过放大特定信号从而调节细胞增殖、凋亡、迁移和侵袭等关键过程潜在地驱动胃癌发生、发展。因此,深入研究ceRNA调控网络相关正反馈环路对于揭示胃癌的发病机制、发现新的潜在治疗靶点具有重要意义。本文综述了ceRNA调控网络相关正反馈环路在胃癌中的作用及其分子机制,并展望其在胃癌治疗中的应用前景。Gastric cancer severely affects human health and has become a significant health issue of global concern.In its complex pathogenesis,genetic regulatory networks play an important role.Among them,the competitive endogenous RNA(ceRNA)regulatory network is an important field of research.This network involves the interaction between various types of RNAmolecules,including mRNA,miRNA,lncRNA,and cireRNA etc.They precisely control gene expression through complex regulatory mechanisms,thereby affecting the occurrence and development of gastric cancer.Positive feedback loops are indispensable signaling mechanisms within biological systems;they accelerate or amplify specific biological processes by cyclically enhancing initial signals.They play a crucial role not only in cell growth,development,and response to various physiological and pathological stimuli but also participate in the occurrence and development of tumors in many ways,such as promoting the proliferation and invasion of tumor cells,changing the tumor microenvironment,and increasing the chemoresistance of tumor cells.Positive feedback loops also exist within the ceRNA regulatory network.These loops potentially drive the occurrence and development of gastric cancer by amplifying specific signals to regulate key processes such as cell proliferation,apoptosis,migration,and invasion.Therefore,in-depth study of the positive feedback loops related to the ceRNA regulatory network is of great significance for revealing the pathogenesis of gastric cancer and discovering new potential therapeutic targets.This article reviews the role and molecular mechanisms of ceRNA-related positive feedback loops in gastric cancer and looks forward to their application prospects in the treatment of gastric cancer.

关 键 词：胃癌 竞争性内源RNA 正反馈环路 信号传递 调控网络 发病机制 治疗靶点 分子机制 

分 类 号：R73[医药卫生—肿瘤]