血清pNF-H、PDCD4与老年急性脑梗死患者神经功能缺损、疾病转归的关系  

The relationship between pNF-H,PDCD4 and neurological deficit and disease outcome in elderly patients with acute cerebral infarction

作　　者：王慧词 王欢 赵静怡 吴彤 WANG Huici;WANG Huan;ZHAO Jingyi;WU Tong(No.4 Department of Neurology,Xingtai People's Hospital,Xingtai Hebei 054000,China)

机构地区：[1]邢台市人民医院神经内四科,河北邢台054000 [2]邢台市人民医院检验科,河北邢台054000

出　　处：《中国急救复苏与灾害医学杂志》2025年第3期329-332,共4页China Journal of Emergency Resuscitation and Disaster Medicine

基　　金：河北省2025年度医学科学研究课题(20251405)。

摘　　要：目的分析血清神经丝蛋白H磷酸化亚型(pNF-H)、程序性细胞死亡因子4(PDCD4)与老年急性脑梗死患者神经功能缺损、疾病转归的关系。方法选择2021年1月—2023年1月经邢台市人民医院收治的128例老年急性脑梗死患者作为观察组,根据美国国立卫生院卒中量表(NIHSS)评分分为轻度组(n=56)、中度型(n=44)、重度组(n=28),根据疾病转归情况分为恶化组(n=30)、转归组(n=98)。另选取同期体检健康者100例作为健康对照组。所有纳入对象入院后24h内采用酶联免疫吸附法检测血清pNF-H、PDCD4水平,并进行各组间比较。采用Pearson相关分析血清pNF-H、PDCD4与NIHSS评分的关系,采用多因素Logistic回归分析影响因素。结果观察组血清pNF-H、PDCD4水平均明显高于健康对照组(P<0.05);重度组老年急性脑梗死血清pNF-H、PDCD4水平均明显高于中度组、轻度组(P<0.05),中度组血清pNF-H、PDCD4水平均明显高于轻度组(P<0.05)。Pearson相关分析显示,老年急性脑梗死患者血清pNF-H与NIHSS评分呈正相关(r=0.663,P<0.05),血清PDCD4与NIHSS评分呈正相关(r=0.453,P<0.05)。恶化组老年急性脑梗死患者血清pNF-H、PDCD4水平均明显高于归转组(P<0.05)。单因素、多因素Logistic逐步回归分析显示,血清LDL-C(OR=3.804,95%CI:1.871~7.733)、pNF-H(OR=4.768,95%CI:2.229~10.201)、PDCD4(OR=3.904,95%CI:2.396~6.360)均是影响老年急性脑梗死疾病转归的危险因素(P<0.05)。结论老年急性脑梗死患者血清pNFH、PDCD4水平均升高,二者与神经功能缺损、疾病转归密切相关,可作为评估年急性脑梗死疾病转归的有效生物学指标。Objective To studu the relationship between phosphorylated subtype of serum neurofilament protein H(pNF-H),programmed cell death factor 4(PDCD4)and nneurological deficit and disease outcome in elderly cases with acute cerebral infarction(ACI).Methods A total of 128 elderly cases with ACI were conducted on this study.All patientsas observation groupwere divided into mild group(n=56),moderate group(n=44)and severe group(n=28)according to the score of National Institutes of Health Stroke Scale(NIHSS).According to the disease outcome,they were divided into worsening group(n=30)and outcome group(n=98).100 healthy people served as control group.Serum levels of pNF-H and PDCD4 were detected by enzyme-linked immunosorbent assay within 24 hours after admission.Pearson correlation was used to analyze the relationship between serum pNF-H,PDCD4 and NIHSS score,and ROC was used to evaluate the diagnostic value of serum pNF-H and PDCD4 in the disease outcome of elderly patients with ACI.The factors affecting the disease outcome in elderly patients with ACI were analyzed by multiple Logistic regression.Results Serum levels of pNF-H and PDCD4 in observation group were higher as compared with control group(P<0.05).pNF-H and PDCD4 in severe group were higher than those in moderate group and mild group(P<0.05);pNF-H and PDCD4 in moderate group were higher than those in mild group(P<0.05).Pearson correlation analysis showed that pNF-H and PDCD4were positively correlated with NIHSS score in elderly patients with ACI(r=0.663,P<0.05;r=0.453,P<0.05 respectively).The levels of serum pNF-H and PDCD4 of elderly cases with ACI in the worsening group were higher than those in outcome group(P<0.05).Serum LDL-C(OR=3.804,95%CI:1.871-7.733),pNF-H(OR=4.768,95%CI:2.229-10.201),PDCD4(OR=3.904,95%CI:2.396-6.360)were all risk factors in elderly patients with ACI(P<0.05).Conclusion Serum pNF-H and PDCD4 levels are elevated in elderly patients with ACI and are positively correlated with neurological deficits and disease outcome.It can be used as an eff

关 键 词：老年人 急性脑梗死 神经丝蛋白H磷酸化亚型 程序性细胞死亡因子4 神经功能缺损 疾病转归 

分 类 号：R743.3[医药卫生—神经病学与精神病学]