3D printing for tissue/organ regeneration in China  

中国3D打印在再生医学研究中的进展

作　　者：Chaofan He Jiankang He Chengtie Wu Changshun Ruan Qi Gu Yongqiang Hao Yang Wu Shuo Bai Xiaoxiao Han Liliang Ouyang Jun Yin Hongzhao Zhou Zhuo Xiong Maobin Xie Lei Shao Jing Nie Liang Ma Cijun Shuai Changchun Zhou Xin Zhao Xuetao Shi Mengfei Yu Jiayin Fu Peng Wen Huixia Xuan Yuan Pang Yan’en Wang Yuan Sun Ziqi Gao Abdellah Aazmi Jingbo Zhang Tianhong Qiao Qixiang Yang Ke Yao Mao Mao Jianxin Hao Pinpin Wang Jirong Yang Huawei Qu Xinhuan Wang Xin Liu Shen Ji Shasha Liu Jingke Fu Bingxian Lu Mohan Wu Feng Chen Zihao Zheng Boqing Zhang Muyuan Chai Chaoying Zhang Mouyuan Sun Bo Peng Huayong Yang Yong He 何超凡;贺健康;吴成铁;阮长顺;顾奇;郝永强;吴洋;白硕;韩晓筱;欧阳礼亮;尹俊;周竑钊;熊卓;谢茂彬;邵磊;聂晶;马梁;帅词俊;周长春;赵昕;施雪涛;俞梦飞;傅佳寅;温鹏;轩慧霞;庞媛;汪焰恩;孙元;高梓祺;Abdellah Aazmi;张景波;乔天鸿;杨棋翔;姚克;毛茅;郝建新;王品品;杨继榕;屈华伟;王新环;刘鑫;季申;刘莎莎;符静珂;卢炳先;吴沫邯;陈锋;郑子豪;张勃庆;柴牧原;张超颖;孙谋远;彭勃;杨华勇;贺永(浙江大学机械工程学院流体动力基础件与机电系统全国重点实验室,杭州市310027;浙江大学机械工程学院浙江省三维打印工艺与装备重点实验室,杭州市310027;西安交通大学精密微纳制造技术全国重点实验室,西安市710049;中国科学院上海硅酸盐研究所高性能陶瓷和超微结构国家重点实验室,上海市200050;中国科学院深圳先进技术研究院生物医药与技术研究所人体组织与器官退行性研究中心,深圳市518055;中国科学院大学,北京市100049;中国科学院动物研究所器官再生与智造重点实验室(膜生物学国家重点实验室),北京市100101;北京干细胞与再生医学研究院,北京市100101;上海骨科创新器械与个性化医学工程技术研究中心,上海市医学3D打印技术临床转化工程研究中心,上海市200011;哈尔滨工业大学(深圳)生物医工学院,深圳市518055;中国科学院过程工程研究所生化工程国家重点实验室,北京市100190;中国科学院过程工程研究所生物药制备与递送重点实验室,北京市100190;湖南大学国家高效磨削工程技术研究中心,长沙市410082;清华大学机械工程系生物制造中心,北京市100084;清华大学高端装备界面科学与技术全国重点实验室,北京市100084;广州医科大学附属第四医院,广州市511436;广州医科大学生物医学工程学院,广州市511436;宁波大学智能医学与生物医学工程研究院,宁波市315211;太原理工大学人工智能�

机构地区：[1]State Key Laboratory of Fluid Power and Mechatronic Systems,School of Mechanical Engineering,Zhejiang University,Hangzhou 310027,China [2]Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province,School of Mechanical Engineering,Zhejiang University,Hangzhou 310027,China [3]State Key Laboratory for Manufacturing Systems Engineering,Xi’an Jiaotong University,Xi’an 710049,China [4]State Key Laboratory of High Performance Ceramics and Superfine Microstructure,Shanghai Institute of Ceramics,Chinese Academy of Sciences,Shanghai 200050,China [5]Research Center for Human Tissue and Organ Degeneration,Institute of Biomedicine and Biotechnology,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China [6]University of Chinese Academy of Sciences,Beijing 100049,China [7]Key Laboratory of Organ Regeneration and Reconstruction,State Key Laboratory of Membrane Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China [8]Beijing Institute for Stem Cell and Regenerative Medicine,Beijing 100101,China [9]Shanghai Engineering Research Center of Innovative Orthopaedic Instruments and Personalized Medicine,Clinical and Translational Research Center for 3D Printing Technology,Shanghai 200011,China [10]School of Biomedical Engineering,Harbin Institute of Technology(Shenzhen),Shenzhen 518055,China [11]State Key Laboratory of Biochemical Engineering,Institute of Process Engineering,Chinese Academy of Sciences,Beijing 100190,China [12]Key Laboratory of Biopharmaceutical Preparation and Delivery,Institute of Process Engineering,Chinese Academy of Sciences,Beijing 100190,China [13]National Engineering Research Centre for High Efficiency Grinding,Hunan University,Changsha 410082,China [14]Biomanufacturing Center,Department of Mechanical Engineering,Tsinghua University,Beijing 100084,China [15]State Key Laboratory of Tribology in Advanced Equipment,Tsinghua University,Beijing 100084,China [16]The Fourth Affiliated Hospital of Guangzhou Medical University,Guangzhou 51

出　　处：《Bio-Design and Manufacturing》2025年第2期169-242,I0001,I0002,共76页生物设计与制造(英文)

基　　金：supported by the National Natural Science Foundation of China(Nos.52325504,52235007,and T2121004).

摘　　要：As surgical procedures transition from conventional resection to advanced tissue-regeneration technologies,human disease therapy has witnessed a great leap forward.In particular,three-dimensional(3D)bioprinting stands as a landmark in this setting,by promising the precise integration of biomaterials,cells,and bioactive molecules,thus opening up a novel avenue for tissue/organ regeneration.Curated by the editorial board of Bio-Design and Manufacturing,this review brings together a cohort of leading young scientists in China to dissect the core functionalities and evolutionary trajectory of 3D bioprinting,by elucidating the intricate challenges encountered in the manufacturing of transplantable organs.We further delve into the translational pathway from scientific research to clinical application,emphasizing the imperativeness of establishing a regulatory framework and rigorously enforcing quality-control measures.Finally,this review outlines the strategic landscape and innovative achievements of China in this field and provides a comprehensive roadmap for researchers worldwide to propel this field collectively to even greater heights.随着外科手术从传统的切除术向先进的组织再生技术转变,人类疾病治疗取得了巨大飞跃。其中,3D生物打印技术作为这一领域的里程碑,有望实现生物材料、细胞和生物活性分子的精准整合,为组织/器官再生开辟了一条新途径。本综述由《生物设计与制造(英文)》编辑部策划,汇集了一批中国一线的青年科学家,通过阐述在制造可移植器官过程中遇到的复杂挑战,深入剖析了3D生物打印的核心功能和演进轨迹。我们还进一步探讨了从科学研究到临床应用的转化路径,强调了建立监管框架和严格执行质量控制措施的必要性。最后,本综述概述了中国在这一领域的战略布局和创新成果,并为全球研究人员提供了一份全面的路线图,以共同推动这一领域迈向更高水平。

关 键 词：3D printing BIOPRINTING Tissue engineering Regenerative medicine 

分 类 号：R73[医药卫生—肿瘤]