血清炎症标志物与出血性脑小血管病的相关性  

Association between serum inflammatory markers and hemorrhagic cerebral small vessel disease

作　　者：王鸿 易芳[1,2] 谷文萍[2,3,4] WANG Hong;YI Fang;GU Wenping(Department of Geriatric Neurology,Xiangya Hospital of Central South University,Changsha,Hunan 410008,China;National Clinical Research Center for Geriatric Disorders(Xiangya Hospital of Central South University),Changsha,Hunan 410008,China;Department of Neurology,Xiangya Hospital of Central South University,Changsha,Hunan 410008,China;Clinical Research Center for Cerebrovascular Disease of Hunan Province(Xiangya Hospital of Central South University),Changsha,Hunan 410008,China)

机构地区：[1]中南大学湘雅医院老年神经内科,湖南长沙410008 [2]国家老年疾病临床医学研究中心(中南大学湘雅医院),湖南长沙410008 [3]中南大学湘雅医院神经内科,湖南长沙410008 [4]湖南省脑血管疾病临床医学研究中心(中南大学湘雅医院),湖南长沙410008

出　　处：《国际神经病学神经外科学杂志》2025年第1期77-85,共9页Journal of International Neurology and Neurosurgery

基　　金：湖南省重点研发计划(2023SK2019);国家自然科学基金(82371343);湖南省自然科学基金(2023JJ30966)。

摘　　要：内皮损伤被认为是造成脑小血管病(CSVD)的主要原因,而炎症可导致内皮损伤。越来越多的证据表明,炎症与CSVD的发病及其进展存在关联。血清炎症标志物水平可以直接反映CSVD相关脑卒中的血管内皮损伤程度。然而,目前的研究主要集中在血清炎症标志物与缺血性CSVD的关系上。该文旨在评估血清炎症标志物与出血性CSVD之间的相关性。研究结果表明,与全身炎症标志物相比,血管/内皮功能障碍相关炎症标志物和氧化应激相关炎症标志物与出血性CSVD之间的关联更密切。炎症因子在缺血性和出血性脑卒中中可能有不同的分布模式。该文扩展了对炎症和CSVD之间关系的了解,并提示不同的CSVD表型间可能有不同的潜在机制。Endothelial injury is considered the main cause of cerebral small vessel disease(CSVD),and inflammation can lead to endothelial injury.An increasing number of evidence has shown that inflammation is associated with the development and progression of CSVD.Serum inflammation markers can directly reflect the degree of vascular endothelial injury leading to CSVD-related stroke.However,current studies mainly focus on the association between serum inflammatory markers and ischemic CSVD.This article aims to investigate the association between serum inflammatory markers and hemorrhagic CSVD.Research findings have confirmed that compared with systemic inflammation,vascular/endothelial dysfunction-related inflammatory markers and oxidative stress-related inflammatory markers have a closer association with hemorrhagic CSVD.Inflammatory factors may have different distribution patterns in ischemic and hemorrhagic stroke.This article expands our knowledge in the association between inflammation and CSVD and suggests that different phenotypes of CSVD may have different potential mechanisms.

关 键 词：脑卒中 脑小血管病 炎症 内皮损伤 血脑屏障 

分 类 号：R743[医药卫生—神经病学与精神病学]