Crosstalk Between the Nervous System and Colorectal Cancer  

作　　者：Xi Li Chunshui Ye Min Wang Patrick Kwan Xin Tian Yanke Zhang 

机构地区：[1]Xi Li and Chunshui Ye contributed equally to this review article.Jining Medical University,Jining,272000,China [2]Department of Neurology,Affiliated Hospital of Jining Medical University,Jining,272000,China [3]Department of Gastrointestinal Surgery,Jining No.1 People’s Hospital,Jining,272000,China [4]Department of Neurology,Renji Hospital,Shanghai Jiaotong University School of Medicine,Shanghai,200127,China [5]Department of Neurology,The First Affiliated Hospital of Chongqing Medical University,Chongqing Key Laboratory of Neurology,Chongqing,400016,China [6]Department of Neuroscience,Central Clinical School,Monash University,Melbourne,VIC,3004,Australia [7]Department of Neurology,Alfred Health,Melbourne,VIC,3004,Australia [8]Department of Medicine,Royal Melbourne Hospital,University of Melbourne,Melbourne,VIC,3004,Australia [9]Department of Neurology,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,200080,China

出　　处：《Neuroscience Bulletin》2025年第1期93-106,共14页神经科学通报(英文版)

基　　金：supported by the National Natural Science Foundation of China(81901324);the Youth Innovation Technology Project of Higher School in Shandong Province(2023KJ261).

摘　　要：The nervous system is the dominant regulatory system in the human body.The traditional theory is that tumors lack innervation.However,an increasing number of studies have shown complex bidirectional interactions between tumors and the nervous system.Globally,colorectal cancer(CRC)is the third most common cancer.With the rise of tumor neuroscience,the role of nervous system imbalances in the occurrence and development of CRC has attracted increasing amounts of attention.However,there are still many gaps in the research on the interactions and mechanisms involved in the nervous system in CRC.This article systematically reviews emerging research on the bidirectional relationships between the nervous system and CRC,focusing on the following areas:(1)Effects of the nervous system on colon cancer.(2)Effects of CRC on the nervous system.(3)Treatment of CRC associated with the nervous system.

关 键 词：Nervous system Colorectal cancer Tumor microenvironment Cancer treatment Tumor neuroscience 

分 类 号：R73[医药卫生—肿瘤]