SNORD3B-2 promotes endometrial carcinoma progression by 2'-O-methylation modification of PLK1 and regulating RAB17 alternative splice  

作　　者：Xi Chen Yuping Du Bumin Xie Qianhui Li Yumeng Ji Yang Han Xiujie Sheng Shuo Chen Yang Zhao 

机构地区：[1]Department of Obstetrics and Gynecology,The Third Affiliated Hospital of Guangzhou Medical University,Guangzhou,Guangdong 510150,China [2]Department of Gynecologic Oncology Research Office,The Third Affiliated Hospital of Guangzhou Medical University,Guangzhou,Guangdong 510150,China Guangzhou [3]Key Laboratory of Targeted Therapy for Gynecologic Oncology,The Third Affiliated Hospital of Guangzhou Medical University,Guangzhou,Guangdong 510150,China [4]Guangdong Provincial Key Laboratory of Major Obstetric Diseases,The Third Affiliated Hospital of Guangzhou Medical University,Guangzhou,Guangdong 510150,China [5]Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology,The Third Affiliated Hospital of Guangzhou Medical University,Guangzhou,Guangdong 510150,China [6]Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine,The Third Affiliated Hospital of Guangzhou Medical University,Guangzhou,Guangdong 510150,China

出　　处：《Genes & Diseases》2025年第2期90-93,共4页基因与疾病(英文)

基　　金：supported by the National Natural Science Foundation of China (No.82072854 to Yang Zhao,82272985 to Shuo Chen);the Project for Key Medicine Discipline Construction of Guangzhou Municipality,Guangdong,China (No.2021-2023-17);the Science and Technology Projects in Guangzhou,Guangdong,China (No.202201020093 to Yang Zhao).

摘　　要：Endometrial cancer(EC)is one of the most common gynecological malignant tumors.Further investigation of the potential molecular mechanism of EC is important.Small nucleolar RNA(snoRNA)is a type of non-coding RNA,with an unclear biological function in EC.We found that Box C/D snoRNA SNORD3B-2 participated in EC oncogenesis and development via the PI3K-AKT signaling pathway.

关 键 词：PLK1 PI3K ENDOMETRIAL 

分 类 号：R73[医药卫生—肿瘤]