全息希尔伯特谱分析在特发性震颤和帕金森病震颤分析中的应用价值  

The application value of Holo-Hilbert spectral analysis in the analysis of tremor in Parkinson′s disease and essential tremor

作　　者：隋珂珬 袁维帅 张永庆 Sui Kexu;Yuan Weishuai;Zhang Yongqing(Department of Neurology,Qilu Hospital of Shandong University(Qingdao),Qingdao 266073,China;The First Institute of Oceanography,Ministry of Natural Resources,Qingdao 266061,China)

机构地区：[1]山东大学齐鲁医院(青岛)神经内科,青岛266073 [2]自然资源部第一海洋研究所,青岛266061

出　　处：《中华神经科杂志》2025年第3期261-268,共8页Chinese Journal of Neurology

摘　　要：目的探讨全息希尔伯特谱分析(HHSA)方法在特发性震颤(ET)和帕金森病震颤分析中的应用价值。方法选取2022年1月至2024年4月在山东大学齐鲁医院(青岛)神经内科就诊的以运动症状起病的帕金森病患者59例和ET患者46例,应用加速度仪和肌电图仪记录无负重和负重1000 g条件下的原始震颤信息和肌电活动;分别应用傅里叶转换和HHSA方法进行原始数据转换,比较两种转换方式下的震颤特征,验证HHSA对震颤分析信号转换的有效性。结果59例帕金森病患者和46例ET患者的震颤频率变化经HHSA转换后,均得到调幅频率-载波频率谱,与傅里叶转换方式相比消除了与噪声相关的频谱和不显著的峰值,保持了良好的震颤的独特峰值。帕金森病组患者记录的主峰频率为4~6 Hz,ET组患者记录的主峰频率为6~12 Hz,两组患者HHSA记录的主峰频率均与傅里叶数据转换相同。帕金森病患者优势上肢静止状态下傅里叶转换和HHSA转换的震颤峰频率分别为(4.93±0.73)Hz和(4.83±0.93)Hz,两组比较差异无统计学意义(t=0.371,P=0.695)。ET患者左上肢傅里叶转换和HHSA转换的震颤峰频率分别为(8.59±2.23)Hz和(8.57±2.29)Hz(t=0.273,P=0.968),右上肢分别为(8.09±1.87)Hz和(8.20±2.11)Hz(t=0.141,P=0.890),左右上肢两种转换方式的震颤峰频率比较差异均无统计学意义。在傅里叶转换方式下出现谐波的帕金森病患者和ET患者经HHSA转换后,均未出现谐波。同一肢体相同状态下两种转换方式的峰频率无显著差异。结论在帕金森病和ET患者震颤频率计算方面,HHSA与傅里叶转换的有效性和准确性一致,HHSA能够纠正傅里叶转换的谐波问题且调幅频率-载波频率谱可用于加速计与肌电数据的关系分析,为震颤机制研究提供可能的途径。ObjectiveTo explore the application value of Holo-Hilbert spectral analysis(HHSA)in the analysis of tremor in Parkinson′s disease(PD)and essential tremor(ET).MethodsA total of 59 patients with PD with motor symptoms and 46 patients with ET were selected from the patients visiting the Department of Neurology,Qilu Hospital of Shandong University(Qingdao)between January 2022 and April 2024,and the original tremor information and myoelectric activity were recorded by accelerometer and electromyography under the condition of no weight bearing and 1000 g weight bearing.Fourier transform(FT)and HHSA were used to convert the original data,and the effectiveness of HHSA for tremor analysis was verified by comparing the tremor characteristics under the two conversion methods.ResultsThe tremor data of 59 PD patients and 46 ET patients were converted by HHSA,and the amplitude modulation frequency-carrier frequency spectrum was obtained;and compared with FT,the noise-related spectrum and insignificant peaks were eliminated,and the uniqueness of tremor was maintained.And the tremor peak frequencies of PD patients under the two methods were similar,both being 4-6 Hz;the tremor peak frequencies of ET patients under the two methods were also similar,both being 6-12 Hz.The tremor peak frequencies of FT and HHSA transform in the upper limb resting state of PD patients were(4.93±0.73)Hz and(4.83±0.93)Hz,respectively,with no statistically significant difference between the two groups(t=0.371,P=0.695).The tremor peak frequencies of FT and HHSA transform in the left upper limbs of ET patients were(8.59±2.23)Hz and(8.57±2.29)Hz,respectively(t=0.273,P=0.968),in the right upper limbs were(8.09±1.87)Hz and(8.20±2.11)Hz,respectively(t=0.141,P=0.890),both with no statistically significant differences.There were no significant differences in the tremor peak frequencies of the two methods in the same limb and the same state.PD patients and ET patients who showed harmonics under FT did not show harmonics after HHSA transform.ConclusionsT

关 键 词：帕金森病 特发性震颤 全息希尔伯特频谱分析 震颤分析 

分 类 号：R742.5[医药卫生—神经病学与精神病学]