帕金森病脑深部电刺激术后表现为节段性肌张力障碍的剂峰异动1例  

Peak-dose dyskinesia presenting as segmental dystonia after deep brain stimulation in Parkinson′s disease:a case report

作　　者：陈琳[1] 布燕娇 余雨雯 陈永兴 雷小光 Chen Lin;Bu Yanjiao;Yu Yuwen;Chen Yongxing;Lei Xiaoguang(First Department of Neurology,the First Affiliated Hospital of Kunming Medical University,Kunming 650032,China)

机构地区：[1]昆明医科大学第一附属医院神经内一科,昆明650032

出　　处：《中华神经科杂志》2025年第3期303-308,共6页Chinese Journal of Neurology

基　　金：国家自然科学基金(82160233);云南基础研究计划(202201AY070001-071)。

摘　　要：左旋多巴和脑深部电刺激(DBS)治疗帕金森病引起节段性肌张力障碍很少被描述,在临床实践中可能对其认识不足。文中报道1例双侧丘脑底核的DBS术后表现为眼睑痉挛、口下颌肌张力障碍、斜颈和左上肢肌张力障碍等节段性肌张力障碍的剂峰异动患者,回顾了帕金森病相关的肌张力障碍,包括治疗前和使用药物以及DBS治疗后出现的肌张力障碍表现形式,以期增加临床医生对治疗帕金森病患者过程中出现的运动障碍的症状识别,利于调整治疗方案,改善患者预后。Segmental dystonia caused by levodopa and deep brain stimulation(DBS)in Parkinson′s disease(PD)has been described rarely and may be underrecognized in clinical practice.A case of peak-dose dyskinesia with segmental dystonia,including blepharospasm,jaw dystonia,torticollis,and dystonia in the left upper limb,after bilateral subthalamic nucleus DBS,is reported.The literatures on PD-related dystonia,including dystonia manifestations before and after treatment with medication and DBS,are reviewed to enhance clinicians′recognition of movement disorders occurring during the treatment of PD and to improve patient outcomes.

关 键 词：帕金森病 肌张力障碍 左旋多巴诱发的异动症 脑深部电刺激术 

分 类 号：R74[医药卫生—神经病学与精神病学]