硒中毒性脑病患者1例的神经影像学表现  

Neuroimaging in a case of selenium toxic encephalopathy

作　　者：周潇依 毛志群 赵志鸿[1] Zhou Xiaoyi;Mao Zhiqun;Zhao Zhihong(Department of Neurology,the First Affiliated Hospital of Hunan Normal University/Hunan Provincial People′s Hospital,Changsha 410005,China;Department of Radiology,the First Affiliated Hospital of Hunan Normal University/Hunan Provincial People′s Hospital,Changsha 410005,China)

机构地区：[1]湖南师范大学附属第一医院/湖南省人民医院神经内科,长沙410005 [2]湖南师范大学附属第一医院/湖南省人民医院放射科,长沙410005

出　　处：《中华神经科杂志》2025年第3期308-312,共5页Chinese Journal of Neurology

摘　　要：中毒性脑病是指各类有害物质中毒引起的以中枢神经系统损害为主要临床表现的一组疾病。既往报道的硒中毒病例仅有一般临床表现特点,报道头部影像学改变的极为罕见。本文报道1例58岁长期服用含硒膳食补充剂的女性硒中毒患者,出现神经功能损害症状,头颅磁共振成像提示涉及中脑及小脑的不规则异常信号。报道本病例旨在展示硒中毒性脑病的神经系统表现,为该病的临床诊疗及含硒补充剂的标准化使用提供参考。Toxic encephalopathy is a term used to describe a group of diseases that are caused by poisoning with a variety of harmful substances.The main clinical manifestation of these diseases is damage to the central nervous system.Previously reported cases of selenium poisoning had only general clinical manifestations,and head imaging changes were rarely reported.This article reports a 58 year-old selenium-poisoned female patient who had been taking a selenium-containing dietary supplement for a long period of time and subsequently developed neurological impairment.The head magnetic resonance imaging indicated the presence of irregular and abnormal signals in the midbrain and cerebellum.The objective of reporting this case is to show the neurological manifestations of selenium toxic encephalopathy and to provide references for the clinical diagnosis and treatment of this disease,as well as the standardized utilisation of selenium-containing supplements.

关 键 词：硒 中毒 营养保健品 神经系统 中毒性脑病 

分 类 号：R74[医药卫生—神经病学与精神病学]