帕金森病发病及进展过程中小脑的作用  

The role of the cerebellum in the onset and progression of Parkinson′s disease

作　　者：廖梦诗 张玉虎[1] Liao Mengshi;Zhang Yuhu(Department of Neurology,Guangdong Provincial People′s Hospital,Southern Medical University(Guangdong Academy of Medical Sciences),Guangdong Neuroscience Institute,Guangzhou Key Laboratory of Diagnosis and Treatment for Neurodegenerative Diseases,Guangzhou 510080,China)

机构地区：[1]南方医科大学附属广东省人民医院(广东省医学科学院)神经科、广东省神经科学研究所、广州市神经退行性疾病诊治研究重点实验室,广州510080

出　　处：《中华神经科杂志》2025年第3期320-325,共6页Chinese Journal of Neurology

基　　金：国家自然科学基金(82071419);广州市科技重点研发计划(202206010086);广州市神经退行性疾病诊治研究重点实验室项目(202201000005)。

摘　　要：帕金森病是一种以运动障碍为主要特征的神经退行性疾病,其病理生理主要涉及基底节-丘脑-皮质通路。近年来,小脑神经网络在帕金森病中的角色逐渐受到关注。小脑不仅参与运动控制,还影响认知和情绪等非运动功能。通过与基底节和大脑皮质的广泛连接,小脑在帕金森病的神经网络调控中发挥着重要作用。文中综述了帕金森病患者小脑的结构功能及其病理生理变化,以及小脑神经网络如何与基底节-丘脑-皮质通路互动,进而影响帕金森病的运动和非运动功能,旨在为理解小脑在帕金森病发病机制中的作用提供新的视角。Parkinson's disease(PD)is a neurodegenerative disorder primarily characterized by motor dysfunction,with its pathophysiology mainly involving the basal ganglia-thalamocortical pathway.In recent years,the role of cerebellar neural networks in PD has garnered increasing attention.The cerebellum not only plays a role in motor control but also influences non-motor functions such as cognition and emotion.Through its extensive connections with the basal ganglia and cerebral cortex,the cerebellum is critically involved in regulating neural networks in PD.This review summarizes the structural and functional changes of the cerebellum in PD patients,as well as the pathophysiological interactions between cerebellar networks and the basal ganglia-thalamocortical pathway,which collectively impact both motor and non-motor functions in PD.The aim of the review is to provide a new perspective on the role of the cerebellum in the pathogenesis of PD.

关 键 词：帕金森病 小脑 神经环路 神经递质 病理生理学 

分 类 号：R742.5[医药卫生—神经病学与精神病学]