帕金森病多汗症的诊断方法进展  

Research progress on diagnostic methods of hyperhidrosis in Parkinson′s disease

作　　者：谢妙贤 刘慧菁 苏闻[1] Xie Miaoxian;Liu Huijing;Su Wen(Department of Neurology,Beijing Hospital,National Center of Gerontology,Institute of Geriatric Medicine,Chinese Academy of Medical Sciences,Peking University Fifth School of Clinical Medicine,Beijing 100730,China)

机构地区：[1]北京医院神经内科、国家老年医学中心、中国医学科学院老年医学研究院、北京大学第五临床医学院,北京100730

出　　处：《中华神经科杂志》2025年第3期325-329,共5页Chinese Journal of Neurology

基　　金：国家重点研发计划(2020YFC2006404,2020YFC2006402,2020YFC2006400);国家重大疾病多学科合作诊疗能力建设项目(FTJ19-03)。

摘　　要：帕金森病是进行性神经退行性疾病中最常见的疾病之一,其临床症状包括运动症状和非运动症状。运动症状是较容易被观察到的症状,包括静止性震颤、肌强直和运动迟缓。非运动症状包括神经精神症状、痴呆、睡眠障碍、流涎、疲劳、疼痛、直立性低血压、胃肠功能障碍、泌尿功能障碍、多汗和嗅觉受损等。相比运动症状,帕金森病非运动症状经常被忽视。在临床中,我们发现有些患者在发病前就存在多汗的表现,随着帕金森病进展,这种多汗症状越发加重,引起严重的睡眠问题,甚至发展到抑郁、焦虑,严重影响患者日常生活。多汗症是帕金森病中研究较少的非运动症状之一,本文将对帕金森病患者多汗症的诊断方法最新进展进行阐述与总结。Parkinson′s disease(PD)is one of the most common progressive neurodegenerative diseases,with clinical symptoms that include motor and non-motor symptoms.Motor symptoms,including static tremor,myotonia and bradykinesia,are the most commonly observed symptoms.Non-motor symptoms include neuropsychiatric symptoms,dementia,sleep disorders,salivation,fatigue,pain,orthostatic hypotension,gastrointestinal dysfunction,urinary dysfunction,hyperhidrosis,and impaired smell.Compared with motor symptoms,non-motor symptoms are not prominent,but seriously affect the daily life of patients.In clinical practice,some patients have hyperhidrosis before the onset of the disease.With the progression of PD,this hyperhidrosis symptom becomes more and more aggravated,causing serious sleep problems and even developing into depression and anxiety,which seriously affects the daily life of patients.Hyperhidrosis is one of the least studied non-motor symptoms in PD.This article will discuss the diagnosis of hyperhidrosis in PD patients,and summarize the latest progress of hyperhidrosis in PD patients.

关 键 词：帕金森病 自主神经系统疾病 多汗症 诊断 非运动症状 

分 类 号：R742.5[医药卫生—神经病学与精神病学]