Q fever diagnosis by metagenomic next generation sequencing:A case report  

作　　者：Li Qiong Qi Xin Gao Wei Wang Fang Yan Peng 

机构地区：[1]Department of Pulmonary and Critical Care Medicine,China Aerospace Science&Industry Corporation 731 hospital,Beijing 100074,China [2]Department of Infection Disease,China Aerospace Science&Industry Corporation 731 hospital,Beijing 100074,China

出　　处：《感染控制(英文)》2024年第2期63-67,共5页

摘　　要：Q fever is a zoonotic infectious disease caused by the intracellular bacterial pathogen Coxiella burnetii,which often manifests clinically as a fever,rash,and swollen lymph nodes.As these clinical symptoms are nonspecific,the diagnosis of Q fever is challenging.Here,we described a case of Q fever that mainly manifested as fever and provide new perspectives for the diagnosis and treatment of Q fever patients.A female patient,who presented at our hospital with a fever on 3 May,2023,responded poorly to antibiotic treatment and had no clear diagnosis.Using the metagenomic next generation sequencing(mNGS)technique,the patient was diagnosed with Q fever and the symptoms were alleviated following the administration of doxycycline.In conclusion,Q fever infection is rare in clinic but its diagnosis can be aided by mNGS.Rapid diagnosis of Q fever allows for early initiation of anti-infection therapy,which improves the prognosis of patients.

关 键 词：Q fever Coxiella burneti metagenomic next generation sequencing 

分 类 号：R73[医药卫生—肿瘤]