Analysis of Factors Influencing Plasma Concentration of Rifampicin in Patients with Pulmonary Tuberculosis  

作　　者：Jia Zhou Ai-Xian Huang Hong-Fa Tan Yu-Ting Ma Yan Liang Chun-Xiong Su 

机构地区：[1]Department of Blood Purification,Guangxi AIDS Clinical Treatment Center,The Fourth People's Hospital of Nanning,Nanning 530023,China

出　　处：《感染控制(英文)》2024年第1期68-77,共10页

基　　金：supported by Xingning District Scientific Research and Technology Development Project(#2021A11).

摘　　要：Objective To analyze the factors influencing the rifampicin blood concentration in patients with tuberculosis and provide a scientific basis for clinical physicians to formulate anti-tuberculosis treatment plans.Methods In total,183 inpatients with pulmonary tuberculosis treated at Nanning Fourth People’s Hospital from July 2021 to April 2023 were divided into 4 groups:the standard treatment group(n=92),tuberculosis with HIV co-infection group(n=26),hemodialysis group(n=63),and co-infection with hemodialysis group(n=2).The plasma drug concentrations and influencing factors in each group were analyzed at 2,4,and 6 hours after administration of rifampicin.According to the peak rifampicin plasma concentration(8–24μg/mL)at 6 hours,the patients were also divided into a low-concentration group(<8μg/mL)and normal-concentration group(≥8μg/mL).Binary logistic regression was used to analyze the factors influencing the rifampicin plasma concentration.Results There was a statistically significant difference in the rifampicin plasma concentration among the groups at 6 hours(P<0.05),but not at 2 and 4 hours(P>0.05).Univariate analysis showed that the urea nitrogen level,creatinine level,dose administered,and hemodialysis affected the rifampicin plasma concentration(P<0.05).Binary logistic regression analysis showed that the administered dose was positively correlated with the rifampicin plasma concentration(odds ratio,4.591;95%confidence interval,1.494–14.103).However,multivariate analysis showed that age,urea nitrogen level,creatinine level,HIV infection,and hemodialysis did not have a significant effect on the rifampicin plasma concentration(P>0.05).Conclusion The influencing factors,including hemodialysis,discussed in this article have little effect on the rifampicin plasma concentration in patients with tuberculosis.Patients undergoing maintenance hemodialysis can take rifampicin before the procedure without the need to increase the dosage.

关 键 词：HEMODIALYSIS RIFAMPICIN plasma concentration pulmonary tuberculosis influencing factors 

分 类 号：R69[医药卫生—泌尿科学]