酒精性慢性胰腺炎急性发作相关因素分析:一项多中心回顾性研究  

Analysis of factors associated with acute on alcoholic chronic pancreatitis:a multicenter retrospective study

作　　者：刘文静[1,2] 陈升鑫 陈德鑫 方开萱 梁雅文 李明阳[2] 翟亚奇[2] Liu Wenjing;Chen Shengxin;Chen Dexin;Fang Kaixuan;Liang Yawen;Li Mingyang;Zhai Yaqi(Chinese PLA Medical School,Beijing 100853,China;Department of Gastroenterology,The First Medical Centre of Chinese PLA General Hospital,Beijing 100853,China)

机构地区：[1]解放军总医院解放军医学院,北京100853 [2]解放军总医院第一医学中心消化内科医学部,北京100853

出　　处：《中华胃肠内镜电子杂志》2024年第4期248-252,共5页Chinese Journal of Gastrointestinal Endoscopy(Electronic Edition)

基　　金：“十四五”国家重点研发计划(2022YFC2503603)

摘　　要：目的探讨酒精性慢性胰腺炎急性发作的影响因素,为早期识别并预防急性发作提供依据。方法回顾性收集2010年1月至2024年1月国内15家医疗中心和医院首诊为酒精性慢性胰腺炎患者的临床资料,最终183例完整临床资料纳入研究,根据是否因急性发作再次入本院治疗分为急性发作组和非急性发作组。结果急性发作组共收集53例(29%)、非急性发作组共收集130例(71%),多因素Logistic回归结果显示,首诊时尿素氮>7.2 mmol/L、胰管狭窄、胰腺假性囊肿、胰源性门脉高压为酒精性慢性胰腺炎急性发作独立影响因素(P<0.05)。结论首诊时尿素氮>7.2 mmol/L、胰管狭窄、胰腺假性囊肿是酒精性慢性胰腺炎急性发作的独立保护因素,胰源性门脉高压是其独立危险因素。Objective To explore the influence factors of the acute on alcoholic chronic pancreatitis.Methods The clinical data from 15 domestic medical centres and hospitals from January 2010 to January 2024 were collected retrospectively.183 patients with alcohol chronic pancreatitis who were initially diagnosed at a medical center or hospital were started into two cohorts based on whether they had an acute attack that led to a subsequent visit to the same medical center or hospital.Results A total of 53(29%)were collected in the acute attack group and 130(71%)in the non-acute attack group.Multivariate logistic regression results showed that blood urea nitrogen>7.2 mmol/L at the first clinic visit,pancreatic duct stenosis,pancreatic pseudocyst,and pancreatic portal hypertension were independent factors affecting the acute on alcoholic chronic pancreatitis(P<0.05).Conclusion blood urea nitrogen>7.2 mmol/L at the first clinic visit,pancreatic duct stenosis and pancreatic pseudocyst are independent protective factors for acute on alcoholic chronic pancreatitis,and pancreatic portal hypertension is an independent risk factor.

关 键 词：酒精性慢性胰腺炎 急性发作 保护因素 危险因素 

分 类 号：R576[医药卫生—消化系统]