老年男性人群幽门螺杆菌感染与血脂谱的关联研究  

The association between Helicobacter pylori infection and blood lipid profile in elderly male population

作　　者：何妍 檀丽冰 周雯 魏敏 连军松 He Yan;Tan Libing;Zhou Wen;Wei Min;Lian Junsong(Department of Occupational Disease Treatment,Chinese People′s Liberation Army Rocket Force Special Medical Center,Beijing 100082,China;Department of Hematology,Chinese People′s Liberation Army Rocket Force Special Medical Center,Beijing 100082,China;The ninth Health Departments,The Second Medical Center of the PLA General Hospital,Beijing 100853,China)

机构地区：[1]解放军火箭军特色医学中心职业病治疗科,北京100082 [2]解放军火箭军特色医学中心血液科,北京100082 [3]解放军总医院第二医学中心保健九科,国家老年疾病临床医学研究中心,北京100853

出　　处：《中华胃肠内镜电子杂志》2024年第3期171-175,共5页Chinese Journal of Gastrointestinal Endoscopy(Electronic Edition)

基　　金：国家老年疾病临床医学研究中心开放课题(NCRCG-PLAGH-2024005)

摘　　要：目的探讨幽门螺杆菌(helicobacter pylori,Hp)感染与老年男性血脂谱的相关性。方法选取2015年1~12月经解放军总医院健康体检的老年男性人群(≥60岁)为研究对象。Hp感染状况采用13C尿素呼气试验判定。采用多因素Logistic回归模型分析该人群血脂谱与Hp感染的相关性。结果本研究共纳入898例老年体检人员,平均年龄为(75.68±10.22)岁,Hp感染468例,感染率为52.12%。Hp感染组(82例,63.57%)低高密度脂蛋白血症患病率高于非感染组(386例,50.20%)(P=0.005)。多因素Logistic回归结果显示,在调整年龄、血尿素氮、中性粒细胞、淋巴细胞和碱性磷酸酶后,总胆固醇和低密度脂蛋白胆固醇每升高1 mmol/L,Hp感染风险分别升高20.5%(OR=1.205,95%CI:1.030~1.410)和36.1%(OR=1.361,95%CI:1.143~1.620),高密度脂蛋白胆固醇每升高1 mmol/L,Hp感染风险降低37.4%(OR=0.626,95%CI:0.424~0.925)。在较高水平白蛋白和血红蛋白分组中,血脂谱与Hp患病风险的相关性更为显著。结论较高水平的TC、LDL-C水平可能与较高的Hp感染风险有关,而较高水平的HDL-C水平可能与较低的Hp感染风险有关,血脂谱与Hp感染率的关联受到营养状况影响。Objective To explore the correlation between helicobacter pylori(Hp)infection and lipid profile among the old male population.Methods The men more than 60 years old who had physical examination in the Chinese PLA General Hospital from January to December 2015 were recruited as the research objects.Hp infection was determined by 13C urea breath test and lipid profile by automatic biochemical analyzer.Multivariate logistic regression model was used to analyze the possible correlation between serum lipid profile and Hp infection.Results A total of 898 old physical examination personnel was included in this study,with an average age of 75.68±10.22.The study identified 468 instances of Helicobacter pylori infection,representing an infection rate of 52.12%.The prevalence of Low-HDL-C in Hp infectious group was lower than that in non-infectious group(P=0.005).Multivariate logistic regression analysis showed that,after adjusting for age,blood urea nitrogen,neutrophils,lymphocytes and alkaline phosphatase,the risk of Hp infection increased by 20.5%(OR=1.205,95%CI:1.030-1.410)and 36.1%(OR=1.361,95%CI:1.143-1.620)for every 1 mmol/L increment of TC and LDL-C,respectively.the risk of Hp infection decreased by 37.4%(OR=0.626,95%CI:0.424-0.925)for every 1 mmol/L increment of HDL-C.In the group with higher levels of albumin and hemoglobin,the correlation between serum lipid profile and prevalence of Hp infection was more profound.Conclusions Higher levels of TC and LDL-C may be associated with higher prevalence of Hp infection,while higher levels of HDL-C may be associated with lower risk of Hp infection.The association between lipid profile and Hp infectious rate may be affected by nutritional status of old male population.

关 键 词：老年人群 幽门螺杆菌 血脂谱 

分 类 号：R573[医药卫生—消化系统]