趋化因子CXC配体13在中枢神经系统感染中的意义及相关研究进展  

Research progress of CXCL13 in central nervous system infection

作　　者：张钊龙 郑卉 赵丹阳 赵悰怡 刘之琪 张优佳 秦秉玉 Zhang Zhaolong;Zheng Hui;Zhao Danyang;Zhao Congyi;Liu Zhiqi;Zhang Youjia;Qin Bingyu(Department of Critical Care Medicine,Henan Provincial People's Hospital,People's Hospital of Zhengzhou University,Zhengzhou 450003,China;Department of Critical Care Medicine,Henan Provincial People's Hospital,People's Hospital of Henan University,Zhengzhou 450003,China)

机构地区：[1]郑州大学人民医院河南省人民医院重症医学部,郑州450003 [2]河南大学人民医院河南省人民医院重症医学部,郑州450003

出　　处：《中华重症医学电子杂志》2024年第1期54-59,共6页Chinese Journal Of Critical Care & Intensive Care Medicine(Electronic Edition)

摘　　要：中枢神经系统感染(CNSI)是中枢神经系统遭受不同生物病原体入侵,导致相应神经组织受损并出现临床症状的一组疾病的总称,早期确诊、及时彻底治疗和预防并发症的发生是降低患者病死率和后遗症发生率的关键。然而,目前可用的诊断方法的敏感度和特异度,不能完全满足临床需求。趋化因子CXC配体13(CXCL13)是宿主免疫反应的重要支柱,能维持并促进炎症,与中枢神经系统炎症性疾病密切相关。因此,CXCL13被认为是诊治CNSI的潜在生物标志物。本文旨在探讨CXCL13在CNSI中的作用,分析其对诊断CNSI、评估病情进展及疗效的意义。Central nervous system infection(CNSI)is a general term for a group of diseases in which central nervous system is invaded by different pathogens,resulting in damage to the corresponding nerve tissue and clinical symptoms.Early diagnosis and timely and thorough treatment are key steps to reduce mortality and complications.However,the sensitivity and specificity of current diagnostic methods do not fully meet clinical needs.The chemokine CXC ligand 13(CXCL13)is an important pillar of host immune response,which can maintain and promote inflammation,and is closely related to inflammatory diseases in central nervous system.Therefore,CXCL13 is considered a potential biomarker for diagnosis and treatment of CNSI.This article aims to explore the role of CXCL13 in CNSI and analyze its significance in diagnosing CNSI,assessing disease progression and efficacy.

关 键 词：趋化因子CXC配体13 中枢神经系统感染 神经莱姆病 森林脑病 神经梅毒 

分 类 号：R741[医药卫生—神经病学与精神病学]