Research trends and hotspots of intratumor microbiome:A comprehensive visualization and bibliometric study from 2012 to 2024  

作　　者：Chaoyue Xiao Xiang Feng Tiantian Zhao Gouping Ding Yawen Gao 

机构地区：[1]Department of Oncology,The Second Xiangya Hospital,Central South University,Changsha,Hunan 410011,China

出　　处：《Chinese Medical Journal》2025年第3期376-378,共3页中华医学杂志(英文版)

基　　金：This work was supported by the National Natural Science Foundation of China(No.82150006);Chinese Society of Clinical Oncology Research Foundation(Nos.Y-HR2017-117,Y-HH202102-0060);Beijing Medical and Health Foundation(No.YWJKJJHKYJJ-F3046D);Qujiang District Quzhou City Life Oasis Public Service Center(No.BJHA-CRP-040);Wu Jieping Medical Foundation(No.320.6750.2023-05-10)to Yawen Gao.

摘　　要：To the Editor:As early as in the mid-19th century,microbiologists first recognized multiple microorganisms within human tumors.Nevertheless,the perceptions of intratumor microbiome have made little progression during the first 50 years of the 20th century owing to contamination interference,experimental irreproducibility,and technical limitations.Strikingly,in the past decade,the advances in detection techniques and analytical tools have been opening unprecedented opportunities to widely investigate the manifold characteristics of low-biomass intratumor microbiome and host–microbe interplays.In the early second decade of the 21st century,researchers focusing on the intratumor microbiome gradually emerged.Initially,this adventurous perspective failed to draw much attention because tumors were still considered sterile in the mainstream belief at that time.

关 键 词：low biomass microbiome detection techniques analytical tools bibliometric study intratumor microbiome host microbe interplays 

分 类 号：R730.2[医药卫生—肿瘤]