基于术前影像组学的肝内胆管细胞癌淋巴结转移预测的系统性分析  

Meta-analysis of lymph node metastasis prediction of intrahepatic cholangiocarcinoma based on preoperative radiomics

作　　者：陆镜明 韩大为 任耀星 黄天笑 向俊西[1,2,3] 张谞丰[1,2,3] 吕毅[1,2,3] 王傅民 Lu Jingming;Han Dawei;Ren Yaoxing;Huang Tianxiao;Xiang Junxi;Zhang Xufeng;Lyu Yi;Wang Fumin(Department of Hepatobiliary Surgery,National and Local Joint Engineering Center for Precision Surgery and Regenerative Medicine,the First Affliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China;Institute of Future Technology of Xi'an Jiaotong University,Xi'an 710061,China;Institute of Regenerative and Reconstructive Medicine,MED-X Institute,the First Affliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China)

机构地区：[1]西安交通大学第一附属医院肝胆外科,精准外科与再生医学国家地方联合工程中心,710061 [2]西安交通大学未来技术学院,710061 [3]西安交通大学第一附属医院MED-X研究院再生与重建医学研究所,710061

出　　处：《中华肝脏外科手术学电子杂志》2024年第6期852-858,共7页Chinese Journal of Hepatic Surgery(Electronic Edition)

基　　金：国家自然科学基金(82170608);陕西省杰出青年科学基金(2021JC-36);陕西省科技创新研究团队(2022TD-53);西安交通大学附属第一医院临床研究课题重点项目(XJTU1AF-CRF-2023-001);西安交通大学附属第一医院基金(2021QN-15)

摘　　要：目的系统性分析基于术前影像组学的肝内胆管细胞癌(ICC)淋巴结转移的预测价值。方法中文检索词:肝内胆管细胞癌、淋巴结转移、影像组学、影像学检查、CT、MRI、超声、PET-CT。英文检索词:intrahepatic cholangiocarcinoma,lymph node metastasis,radiomics,CT,MRI,ultrasonic,PETCT。主题词检索PubMed、中国知网等国内外数据库中相关研究,检索时限为建库至2023年3月1日,对纳入文献进行提取与分析。采用频数、百分比对数据进行统计描述,对发表年份等采用条形图进行呈现,对提取的影像组学数据以表格进行呈现。结果最终纳入15篇文献,其中英文文献12篇,中文文献3篇。发表时间为2003~2023年,2019年发表最多,达5篇。回顾性队列研究14篇,前瞻性队列研究1篇。中国地区开展研究10篇,韩国3篇,日本2篇。目前主要的影像组学利用方式分为定性数据和定量数据,其中定性数据包括影像上的肿瘤数量、肿瘤大小、肿瘤位置、血管浸润、淋巴结大小、是否有卫星病灶、是否存在坏死或囊性成分、是否存在胆管扩张、形态学分类、病变轮廓是否规则、肝被膜是否回缩、内脏腹膜是否穿孔等;定量数据包括CT值比、标准化摄入值(SUV)最大值、SUV最大值比、Pyradiomics值、IBEX值、表观扩散系数(ADC)等。结论目前在ICC术前影像组学研究领域内,主要的影像组学利用方式分为定性数据和定量数据。其中定性数据参数多,利用较为充分,而定量数据的使用方式上相对频率低、方式单一。Objective To systematically analyze the predictive value for lymph node metastasis of intrahepatic cholangiocarcinoma(ICC)based on preoperative radiomics.Methods Chinese searching words consisted of intrahepatic cholangiocarcinoma,lymph node metastasis,radiomics,imaging examination,CT,MRI,ultrasound and PET-CT.English searching words included intrahepatic cholangiocarcinoma,lymph node metastasis,radiomics,CT,MRI,ultrasonic and PET-CT.Relevant studies were searched in Chinese and international databases such as PubMed and CNKI from the inception date of the databases to March 1,2023,and the included studies were extracted and analyzed.Statistical description was expressed by frequency and percentage.The year of publication was illustrated by bar charts.The extracted radiomic data were presented in tables.Results 15 articles were finally included,including 12 articles in English and 3 in Chinese.The year of publication was ranged from 2003 to 2023,with the largest number of articles(n=5)published in 2019.There were 14 retrospective cohort studies and 1 prospective cohort study.10 studies were performed in China,3 in South Korea and 2 in Japan.At present,radiomic analysis was mainly conduced for qualitative and quantitative data.Qualitative data included the number of tumors,tumor size,tumor site,vascular infiltration,lymph node size,whether satellite lesions,necrotic or cystic components and bile duct dilatation occurred or not,morphological classification,whether the margins of lesions were regular or not,whether hepatic capsule was retracted or not and whether visceral peritoneum was perforated or not,etc.The quantitative data consisted of CT value ratio,maximum standardized uptake value(SUV),maximum SUV ratio,Pyradiomics value,IBEX value and apparent diffusion coefficient(ADC),etc.Conclusions At present,qualitative and quantitative data are mainly employed in the field of preoperative radiomic research for ICC.Among them,qualitative data which comprise more parameters are fully utilized,whereas quantitative data

关 键 词：肝内胆管细胞癌 肝肿瘤 影像组学 淋巴结转移 系统性分析 

分 类 号：R735.7[医药卫生—肿瘤]